The use of 2 or more antipsychotic medications (polypharmacy) for an episode of psychosis is pervasive despite the lack of evidence-based data. It is also associated with higher daily dosing, more frequent use of adjunctive medications such as anticholinergic agents, higher rate of adverse effects and under-utilisation of atypical...

The appropriate treatment of mental disorders implies the rational use of pharmacological, psychological and psychosocial interventions in a clinical and integrated way.1 Psychological treatment methods have been found to be effective in the treatment of mental disorders,2 and group psychoeducation (GPE), a form of psychological or psychosocial treatment has...

In medicine, measures that save the most lives and improved the quality of life of millions have largely been public health measures that in most instances, had been preventive measures. The most obvious examples are the infectious diseases which were – to use the cliché – the scourge of...

Despite the common experience of the world as mostly stable and meaningful, the human nervous system continuously engages with a vast array of ambiguous and constantly changing sensory signals. To organise coherent percepts from the fragmented and unstable sensory signals that constitute experience, and to allow for coordinated interaction...

The architecture of the neurobiology of schizophrenia is complex: it comprises an inherited vulnerability with multiple genes involved, and its interaction with a number of environmental factors. That the onset of psychosis typically occurs during late adolescence and early adulthood is suggestive that additional factors play significant roles along...

Unhealthy diet is a modifiable risk factor in many health conditions, including mental disorders. Nutritional psychiatry is an emerging field that examines the role of diet and nutrition in mental health. Since its beginnings in the 2000s, a notable change in the field was a switch in focus from...