Dear Editor, With the advancements in pharmacogenetics, potential genetic associations with severe cutaneous adverse drug reactions (SCAR)—which include Stevens- Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN)—have been proposed. Lamotrigine is one of the 2 anticonvulsants found to be highly associated with SJS/TEN from the 2008 EuroSCAR study. Several...

In the last decade, our understanding of psoriasis has increased by leaps and bounds, resulting in many new targeted therapies being introduced for those with recalcitrant psoriasis. However, despite the plethora of new treatment options and biologics to treat the most difficult cases of psoriasis, dermatologists are still confronted...

Inter-individual differences in drug responses are well recognised and may be due to genetic or environmental differences. These genetic or environmental influences may also result in inter-ethnic or inter-geographic differences in drug response. Indeed, drug regulatory authorities are beginning to acknowledge these differences. For example, in 1999, the United...

There is an increasing interest in personalised medicine, perhaps none greater than in the field of oncology. The idea of making therapeutic decisions based on an individual’s genetic makeup, with the ability to predict tumour response, as well as minimise toxicity is extremely appealing to the oncologist. This is...