Dear Editor, There is a high burden of genetic disorders in patients admitted to the intensive care unit (ICU), ranging from 45–56%,1,2 and delayed definitive diagnoses with a long diagnostic odyssey often contribute to increased healthcare costs.3 The application of clinical exome sequencing in ICU has been gaining traction, where...

Dear Editor, Acute lower respiratory infections (ALRIs) are a leading cause of under-5 mortality globally—two-thirds could be attributable to respiratory viral infections (RVIs).1,2 The burden of paediatric RVIs in settings of tropical climate with year-long virus circulation is relatively underreported.3,4 Previous studies in these areas have estimated that around 8–11%...

Dear Editor, Cytomegalovirus (CMV) infection is the most common congenital infection.1 A systematic review that included 77 studies from 36 countries reported that the overall prevalence of CMV was 0.67% in their newborn population.1 Among newborns with CMV, it was estimated that 15–20% will suffer from potentially deleterious effects including...

The prevalence of hearing impairment in the local elderly population is not known. Hearing loss prevalence estimates that 25% to 40% of individuals over 65 years of age are hearing impaired. However, there is no universal agreement on the definition of “normal hearing” and comparison between studies that report...

One of the significant milestones in the perinatal care in Singapore is the birth of the Perinatal Society of Singapore in March 1989. This signaled the beginning of increased collaboration between the obstetricians and neonatologists in the management of high-risk pregnancies through multidisciplinary birth defect clinics and high-risk perinatal...

Many cross-sectional and longitudinal studies have reported an association between sensory and cognitive functions in the normal ageing population. Few studies have assessed the association between sensory and cognitive impairment as most studies on cognitive ageing excluded those with sensory and cognitive impairments. This article is available only as a...

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This article is available only as a PDF. Please click on “Download PDF” on top to view the full article.

This article is available only as a PDF. Please click on “Download PDF” on top to view the full article.

There have been significant advances in the understanding of middle ear mechanics and inner ear physiology in the past 2 decades. With increasing exchange and co-operation between clinicians, scientists and engineers, many new and exciting developments have emerged. Many are still in the research stage of development whilst others...

About 1 in 1000 newborns have severe to profound hearing loss and about 5 in 1000 have lesser degrees of loss,1 which suggests that it is the most frequently occurring major birth defect. Unfortunately, for many babies, this disability remains undetected until it is too late to prevent undesirable...

Tetralogy of Fallot (TOF) is the most common cyanotic congenital heart disease with an incidence of approximately 0.5/1000 live births (5% to 7% of congenital heart lesions). In Singapore with a live birth of over 37, 000 per year,1 the expected number of new TOF cases will be approximately...

Neonatologists were caught looking the other way in the early part of the millennium. While they were keenly following the progress of extreme preterms and their travails, preterms born at the other end of the spectrum were being quietly ignored as “well babies”. In July 2005, the National Institute...

Dengue fever (DF) is endemic in India and Singapore, and also causes frequent epidemics. Dengue virus belongs to the Flavivirus genus of the family Flaviviridae and its members include the 4 antigenically related serotypes of dengue virus (DENV 1–4). He also had metastatic squamous cell lung carcinoma and last...

Recurrent apnoea in a term infant is usually pathologic, warranting a thorough aetiologic evaluation. An accurate diagnosis is essential in guiding subsequent management and understanding long-term prognosis. This article is available only as a PDF. Please click on "Download PDF" to view the full article.