• Vol. 40 No. 9, 422–423
  • 15 September 2011

Anticonvulsant Hypersensitivity Syndrome Secondary to Lamotrigine Mimicking a Septic Episode



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Anticonvulsant hypersensitivity syndrome consists of the hallmark features of fever, rash, and lymphadenopathy and multiorgan involvement. We report a case of lamotrigine hypersensitivity that was difficult to diagnose because of comorbid systemic lupus eythrmatosus (SLE), and the presence of clinical features mimicking sepsis due to a zoonosis. The syndrome resolved with the discontinuation of the medication. Timely recognition of this rare but potentially fatal drug reaction is important.

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