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Volume 52, Number 11 November 2023

Gram-negative bacteria are found to be frequently multidrug-resistant and the predominant cause of infections among preterm infants in the neonatal intensive care unit.

Read Burden of antibiotic resistance in infections among very-low-birthweight infants in Singapore, published in the November issue of the Annals.

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Featured

Original Article

Burden of antibiotic resistance in infections among very-low-birthweight infants in Singapore

Nadira Shahrul Baharin and others
Recent reports have described an increased predominance of Gram-negative organisms (Escherichia coli, Klebsiella species ) among invasive bacterial infections in early- and late-onset neonatal sepsis in many settings.1-5 This changing pattern of infections is particularly concerning due to the...
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Original Article

Real-world data on the use of emicizumab in patients with haemophilia A with...

Ming Wei Lee and others
Haemophilia A is an X-linked hereditary bleeding disorder caused by pathogenic genetic variants, which results in a deficiency of factor VIII (FVIII).1 The mainstay of treatment is FVIII replacement, which can be administered as prophylaxis or on-demand.2 While FVIII...
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Review Article

AL amyloidosis: Singapore Myeloma Study Group consensus guidelines on diagnosis, treatment and management

Melinda Tan and others
Amyloidosis refers to disorders characterised by the deposition of insoluble amyloid fibrils, which are pathogenic,1 resulting in organ dysfunction. Amyloidoses differ in the protein precursor undergoing aggregation and downstream target organs implicated. Consequently, clinical manifestations are varied, from localised...
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Original Article

Risk of dementia in the elderly with non-alcoholic fatty liver disease: A nested...

Sung Hwan Yoo and others
Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease affecting about 25% of the general population.1,2 NAFLD has a broad disease spectrum ranging from simple hepatic steatosis to non-alcoholic steatohepatitis (NASH)/liver cirrhosis, resulting in increased risk...
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Editorial

Paradigm shifts in haemophilia A therapy with emicizumab prophylaxis in Asia

Darintr Sosothikul and Chatphatai Moonla
Over the past decade, the development of emicizumab, the first-in-class factor VIII (FVIII)-mimetic monoclonal antibody bispecific to activated factor IX and factor X, has ushered in a significant revolution in non-factor replacement therapy for patients with congenital FVIII deficiency...
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Editorial

Improving management of AL amyloidosis

Yuh Shan Lee, Jeffrey Huang
In this issue of the Annals, Tan et al. on behalf of Singapore Myeloma Study Group presented the consensus guidelines on light chain (AL) amyloidosis.1 This is an encouraging effort as AL amyloidosis is a rare disease, with diagnostic...
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Original Article

Clinical utility of PET/MRI in multiple myeloma

Cinnie Soekojo and others
Multiple myeloma (MM) is a haematological malignancy characterised by abnormal accumulation of malignant plasma cells and is associated with anaemia, renal impairment, hypercalcemia and bone lesions. A sensitive method to detect bone lesions is crucial as it could determine...
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Review Article

Improving visual outcomes in patients with rare paediatric eye diseases

Faye Yu Ci Ng, Poh Lin Tan, Gangadhara Sundar
Rare diseases are generally understood as those that affect less than 1 in 2000–2500 people in the general population.1 They are defined to affect fewer than 200,000 people in the US, lesser than 1 in 2000 people in Europe...
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Commentary

Value the patient as a person: Answering the call for a person-centred model...

Wei Zhen Hong, Jason Phua
There has been a change in patients’ attitudes towards healthcare professionals in recent decades, coupled with an increasingly evident shift in the care paradigm. In 2015, the World Health Organization released a framework of care that recommends healthcare professionals...
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Letter to the Editor

The practice patterns and perceptions of surgeons in Singapore regarding breast-conserving surgery

Sabrina Ngaserin and others
Dear Editor, Breast-conserving surgery (BCS) is often the preferred treatment in operable breast cancer.1 While tumour biology and systemic therapy are major determinants of disease control, surgical effectiveness remains a key factor in ipsilateral breast tumour recurrence.1 As heterogeneity in...
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Letter to the Editor

Outcomes of a targeted congenital cytomegalovirus infection screening approach among infants born ≥35...

Yee Yin Tan and others
Dear Editor, Cytomegalovirus (CMV) is a common cause of congenital viral infection. The estimated incidence of congenital CMV (CCMV) is about 1–6% worldwide, although reliable estimates from Singapore and surrounding countries are unavailable.1,2 Previous local serologic studies among pregnant women...
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Original Article

Association of quality-of-care indicators with asthma outcomes: A retrospective observational study for asthma...

Sean Shao Wei Lam and others
Asthma, a chronic inflammatory disorder of the airways,1 is a common respiratory condition, with an estimated 262 million people affected worldwide.2 In Singapore, 5% of residents aged 18–69 years are affected.3 Despite the high standard of healthcare in Singapore,...
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Call For Papers

The Annals is the official journal of the Academy of Medicine, Singapore. Established in 1972, Annals is the leading medical journal in Singapore which aims to publish novel findings from clinical research as well as medical practices that can benefit the medical community.

Published monthly, online, open-access and peer-reviewed, Annals is indexed in Science Citation Index Expanded, Current Contents/Clinical Medicine and SCOPUS. The journal’s 2022 Impact Factor is 5.2. It is ranked in the first quartile in the competitive category of Medicine (General and Internal) and second among medical journals in Asia. As we are transitioning to an Online Only journal, there may be a delay in PubMed indexing for our content.

The rapidly ageing population and enlarging burden of chronic diseases require a proportionate emphasis on health promotion and disease prevention. A health system that is more data-driven and patient-centric, which leverages the innovative use of technology and digital solutions, will be areas warranting research attention and coverage. The Annals invites submission of manuscripts that advance the scientific basis of clinical knowledge, and the practice of medicine in Singapore and internationally. We welcome submissions that address challenges in the management of chronic diseases (e.g. cancer, cardiovascular diseases, ageing, diabetes mellitus and neurological diseases), and use of technology and digital medicine to improve patient care.

Papers of sufficient merits will be published. Authors will also be notified if their manuscripts are deemed not suitable for publication.

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Cyrus SH Ho, Cornelia YI Chee, Roger CM Ho
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