Current Issue

Volume 53, Number 5 May 2024

Performance of classification criteria for systemic lupus erythematosus (SLE) in Asian childhood-onset SLE (cSLE) population remains unclear as clinical manifestations differ.

This study evaluates the criteria used to diagnose SLE, a disease often referred to as lupus (Latin for "wolf"). It examines an East Asian cohort with childhood onset, predominantly female, with a median diagnosis age of 12.9 years.

Featured

Diagnostic performance of classification criteria for systemic lupus erythematosus: A validation study from Singapore

Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease with a broad spectrum of clinical presentation.1 Clinical diagnosis by rheumatologists remains the gold standard, but the diagnosis is often challenging due to variability in disease expression mimicking other conditions. As...

Delayed presentation is associated with serious bacterial infections among febrile infants: A prospective cohort study

Young infants ≤90 days old are at risk of serious bacterial infections (SBIs) due to their immature immune systems and may develop severe complications resulting in neurocognitive deficits, hearing loss and even mortality.1,2 The diagnosis of SBIs remains challenging...

Prevalence and risk factors of depression and anxiety in primary care

The global prevalence of individuals living with a mental disorder in 2019 was 970 million, with anxiety and depressive disorders being the most common.1 The Singapore Mental Health Study 2016 showed that the lifetime prevalence of at least one...

Holistic preconception care: Providing real-time guidance via a mobile app to optimise maternal and child health

Global fertility rates have decreased by more than half since 1950, recorded at 2.3 births per woman in 2021.1 By 2056, this figure is projected to decline further to 2.09, which falls below the replacement fertility rate of 2.1...

Understanding treatment burden in adults with multimorbidity in the Singapore primary care setting: An exploratory study using the Multimorbidity Treatment Burden Questionnaire

Dear Editor, Patients with multimorbidity often undertake several tasks to manage their health. These include learning about their conditions, taking medications correctly, implementing lifestyle changes, etc., which can be overwhelming and burdensome.1 Their perceptions of the effort required to manage...

Physician sentiments on low-value investigations in Singapore: Part of Choosing Wisely campaign

Dear Editor, Low-value investigations provide marginal benefit and may result in harm to the patient or disproportionate healthcare costs.1 The introduction of Singapore’s Choosing Wisely (CW) campaign in 2012 aims to reduce such investigations.2 CW was designed to encourage conversations...

Factors affecting outcomes among older trauma patients in Singapore: A retrospective observational study

Dear Editor, Singapore faces a rapidly ageing population with its median age projected to be above 45 years by 2030. Our greying demographics is accompanied by a rise in chronic diseases and medication use, including polypharmacy.1 Longer life expectancy and...

Optimising percutaneous valve-in-valve TAVI with bioprosthetic valve fracture

Dear Editor, Percutaneous transcatheter aortic valve implantation (TAVI) has become an established therapy for inoperable patients, for high, intermediate and low surgical-risk patients over 65 years old with severe aortic valve stenosis (AS).1,2 Valve-in-valve (ViV) TAVI is an approved indication...

Group B Streptococcus screening with antenatal culture and intrapartum polymerase chain reaction: A prospective cohort study

Dear Editor, Group B Streptococcus (GBS) is a common genital and gastrointestinal tract commensal in healthy women. Vertical transmission of GBS may cause neonatal early-onset GBS disease (EoGBS), and this is prevented by intrapartum antibiotic prophylaxis (IAP) GBS colonisation,1 coupled...

Comparing the effectiveness, safety and cost of teleconsultation versus face-to-face model of pharmacist-led anticoagulation clinic: A single institution experience

Dear Editor, Teleconsultation-based (TELE) anticoagulation clinic (ACC) is an alternative modality, but its use in Singapore’s clinical setting has not been well studied. In Tan Tock Seng Hospital (TTSH), the TELE ACC service was established to enrol patients who (1)...

2023 clinical practice guidelines on autism spectrum disorder in children and adolescents in Singapore

(illustration by Nata Blackthorn) Autism spectrum disorder (ASD) is a neurodevelopmental condition that presents as differences in social communication and social interaction, together with restricted, repetitive behaviours.1 These social communication and interaction differences, as well as restricted, repetitive behaviours, are...

Promoting evidence-based care for children and adolescents on the autism spectrum

Autism spectrum disorder (ASD) is a neurodevelopmental disorder that has been increasing in worldwide prevalence,1 including Singapore. In this latest issue of the Annals, we share the latest Singapore Clinical Practice Guidelines (CPG) for Autism in Children and Adolescents,...

Call For Papers


The Annals is the official journal of the Academy of Medicine, Singapore. Established in 1972, Annals is the leading medical journal in Singapore which aims to publish novel findings from clinical research as well as medical practices that can benefit the medical community.

Published monthly, online, open-access and peer-reviewed, Annals is indexed in Science Citation Index Expanded, Current Contents/Clinical Medicine and SCOPUS. The journal’s 2022 Impact Factor is 5.2. It is ranked in the first quartile in the competitive category of Medicine (General and Internal) and second among medical journals in Asia. As we are transitioning to an Online Only journal, there may be a delay in PubMed indexing for our content.

The rapidly ageing population and enlarging burden of chronic diseases require a proportionate emphasis on health promotion and disease prevention. A health system that is more data-driven and patient-centric, which leverages the innovative use of technology and digital solutions, will be areas warranting research attention and coverage. The Annals invites submission of manuscripts that advance the scientific basis of clinical knowledge, and the practice of medicine in Singapore and internationally. We welcome submissions that address challenges in the management of chronic diseases (e.g. cancer, cardiovascular diseases, ageing, diabetes mellitus and neurological diseases), and use of technology and digital medicine to improve patient care.

Papers of sufficient merits will be published. Authors will also be notified if their manuscripts are deemed not suitable for publication.

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