Current Issue

Volume 53, Number 1 January 2024

Fecundity of women decreases significantly after the age of 32, and rapidly so after age 37 years.

In this issue, a review reports the optimal and cost-effective timing for elective egg freezing, recommended protocols, cryopreservation techniques, oocyte storage and usage, and pregnancy risks to better guide clinicians in counselling young single women.

Featured

Frailty-aware surgical care: Validation of Hospital Frailty Risk Score (HFRS) in older surgical patients

Frailty is a clinically recognisable state of vulnerability in older people, resulting from age-associated decline in physiological reserves and function across multiple organ systems, such that the ability to cope with acute stressors is compromised.1 Frailty is prevalent among...

Oocytes on ice: Exploring the advancements in elective egg freezing for women

Elective egg freezing (EEF), otherwise known as oocyte cryopreservation for age-related fertility loss, has become a viable option for single women to preserve their fertility.1 It is well known that female fertility decreases gradually, but significantly after the age...

Anti-osteoporosis drugs reduce mortality in cancer patients: A national cohort study of elderly with vertebral fractures

Osteoporotic vertebral fractures (OVFs) are the most prevalent type of fragility fractures, affecting 25% of adults in their early 70s and 43% of those over the age of 80.1,2 Following an OVF, persistence of the vertebral deformity may lead...

Caregiver reported long-term outcomes in children with major trauma and traumatic brain injuries: A single-centre retrospective study

Traumatic injuries in children are a significant cause of mortality and morbidity worldwide.1 Children with major trauma are at risk of poor outcomes.2-4 These include disabilities that require assistance with activities of daily living, intellectual disability and behavioural problems.5...

Freezing hope: Balancing realism and optimism in elective egg freezing

The 2022 White Paper on Singapore Women’s Development, which aimed at a fair and inclusive society where both women and men can pursue their aspirations fully, announced the option for elective egg freezing (EEF) and that the age limit...

Anti-osteoporosis drugs and reduction of mortality in cancer patients

Osteoporosis and cancer share a complex relationship, with each condition influencing the progression and outcomes of the other.1 Multiple factors, such as chemo- and hormonal therapies, and the direct invasion of bone tissue by malignant cells contribute to the...

Strategies to prevent cardiovascular disease in Singapore: A call to action from Singapore Heart Foundation, Singapore Cardiac Society and Chapter of Cardiologists of the Academy of Medicine, Singapore

Despite the success of Singapore’s public health systems in providing medical care through the country, there is still much to be achieved in terms of optimising the cardiovascular (CV) health of its 6 million residents. According to the 2019...

Call for a Singapore National Action Plan for Sepsis (SNAPS): Stop sepsis, save lives

Sepsis is a life-threatening organ dysfunction syndrome caused by a dysregulated host response to an infection.1 It affects up to 48.9 million people globally every year and causes 11 million sepsis-related deaths, accounting for 1 in every 5 deaths...

Normative data for baseline and longitudinal neuropsychological assessments in Singapore

Dear Editor, Neuropsychological assessments play a vital role in the early detection of cognitive disorders. However, the lack of Singapore-specific norms has resulted in a reliance on international, usually Western, norms that potentially reduce the accuracy and reliability of assessments...

Perinatal outcomes of pregnancies affected by COVID-19 in Singapore: A cohort study

Pregnant women and infants were not spared from the coronavirus disease 2019 (COVID-19) after it was first identified in December 2019.1,2 In the beginning of the pandemic, a lack of data on transmission risks and outcomes of pregnancies affected...

Development of immediate and chronic spontaneous urticaria following mRNA COVID-19 vaccination: Tolerability of revaccination and immunological study

Dear Editor, Coronavirus 2019 (COVID-19) vaccination remains one of the key public health measures against the SARS-CoV-2 infection, significantly reducing illness severity and mortality rates. Urticaria and/or angioedema are cutaneous reactions that have been reported in response to messenger...

Redefining seropositive rheumatoid arthritis: Clinical implications of anti-carbamylated protein on remission, radiographic damage and quality of life

Dear Editor, Rheumatoid arthritis (RA) is a chronic disabling disease where continued disease activity translates to irreversible articular damage. Seropositivity for rheumatoid factor (RF) and anticitrullinated protein antibody (ACPA) are markers of poorer prognosis; with increased disease activity, radiographic progression...

Call For Papers


The Annals is the official journal of the Academy of Medicine, Singapore. Established in 1972, Annals is the leading medical journal in Singapore which aims to publish novel findings from clinical research as well as medical practices that can benefit the medical community.

Published monthly, online, open-access and peer-reviewed, Annals is indexed in Science Citation Index Expanded, Current Contents/Clinical Medicine and SCOPUS. The journal’s 2022 Impact Factor is 5.2. It is ranked in the first quartile in the competitive category of Medicine (General and Internal) and second among medical journals in Asia. As we are transitioning to an Online Only journal, there may be a delay in PubMed indexing for our content.

The rapidly ageing population and enlarging burden of chronic diseases require a proportionate emphasis on health promotion and disease prevention. A health system that is more data-driven and patient-centric, which leverages the innovative use of technology and digital solutions, will be areas warranting research attention and coverage. The Annals invites submission of manuscripts that advance the scientific basis of clinical knowledge, and the practice of medicine in Singapore and internationally. We welcome submissions that address challenges in the management of chronic diseases (e.g. cancer, cardiovascular diseases, ageing, diabetes mellitus and neurological diseases), and use of technology and digital medicine to improve patient care.

Papers of sufficient merits will be published. Authors will also be notified if their manuscripts are deemed not suitable for publication.

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