Current Issue

Volume 53, Number 5 May 2024

Performance of classification criteria for systemic lupus erythematosus (SLE) in Asian childhood-onset SLE (cSLE) population remains unclear as clinical manifestations differ.

This study evaluates the criteria used to diagnose SLE, a disease often referred to as lupus (Latin for "wolf"). It examines an East Asian cohort with childhood onset, predominantly female, with a median diagnosis age of 12.9 years.

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Diagnostic performance of classification criteria for systemic lupus erythematosus: A validation study from Singapore

Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease with a broad spectrum of clinical presentation.1 Clinical diagnosis by rheumatologists remains the gold standard, but the diagnosis is often challenging due to variability in disease expression mimicking other conditions. As...

Delayed presentation is associated with serious bacterial infections among febrile infants: A prospective cohort study

Young infants ≤90 days old are at risk of serious bacterial infections (SBIs) due to their immature immune systems and may develop severe complications resulting in neurocognitive deficits, hearing loss and even mortality.1,2 The diagnosis of SBIs remains challenging...

Prevalence and risk factors of depression and anxiety in primary care

The global prevalence of individuals living with a mental disorder in 2019 was 970 million, with anxiety and depressive disorders being the most common.1 The Singapore Mental Health Study 2016 showed that the lifetime prevalence of at least one...

Holistic preconception care: Providing real-time guidance via a mobile app to optimise maternal and child health

Global fertility rates have decreased by more than half since 1950, recorded at 2.3 births per woman in 2021.1 By 2056, this figure is projected to decline further to 2.09, which falls below the replacement fertility rate of 2.1...

2023 clinical practice guidelines on autism spectrum disorder in children and adolescents in Singapore

(illustration by Nata Blackthorn) Autism spectrum disorder (ASD) is a neurodevelopmental condition that presents as differences in social communication and social interaction, together with restricted, repetitive behaviours.1 These social communication and interaction differences, as well as restricted, repetitive behaviours, are...

Prevalence of consumption of illicit drugs and associated factors from a nationwide epidemiological survey: The Singapore Health and Lifestyle Survey

Substance use disorders (SUDs) are characterised by the uncontrolled use of a substance by an individual despite its harmful consequences.1,2 The prevalence of consumption of substances and SUDs varies widely across countries. This difference in prevalence can be attributed...

Healthcare burden of cognitive impairment: Evidence from a Singapore Chinese health study

Individuals with cognitive impairment (CI) are predisposed to injuries, infections and treatment complications,1 have poorer treatment compliance, and face greater difficulties with post-discharge care.2 These challenges, exacerbated by comorbidities,3-6 lead to poorer ambulatory care management, reduced contacts with primary...

Challenges in genetic screening for inherited endocrinopathy affecting the thyroid, parathyroid and adrenal glands in Singapore

In the current landscape of medicine, it is well known that most diseases incorporate a genetic component to some degree. Genetic testing of human diseases originated in the 1950s, and screening for genetic disorders followed a decade after.1 It...

The impact of media reporting of suicides on subsequent suicides in Asia: A systematic review

Globally, around 703,000 people die by suicide annually, 77% of which occur in low- to middle-income countries.1 In 2019, suicide was the 4th leading cause of death among younger adults (15–29 years).1 Approximately 60% of the global suicide rates...

Effect of drug interactions with non-vitamin-K oral anticoagulants on thromboembolic events in patients with nonvalvular atrial fibrillation

Atrial fibrillation (AF), a type of arrhythmia for which the incidence and prevalence are rising in the older population, has become a global epidemic.1 The estimated prevalence of AF is approximately 2% to 4%,2,3 and its prevalence is projected...

Defining breast cancer-related lymphedema (BCRL) prevalence and risk factors: A pragmatic approach to lymphedema surveillance

Breast cancer-related lymphedema (BCRL) is a chronic progressive pathological condition of the lymphatic system that can lead to significant impact on the quality of life after breast cancer treatment.1 It is characterised by swelling and accumulation of protein-rich fluid...

Consensus statements and guideline for the diagnosis and management of plantar fasciitis in Singapore

Plantar fasciitis (PF) is a degenerative disorder of the plantar aponeurosis at the insertion of the plantar fascia into the calcaneus, most commonly at the medial tubercle of the calcaneus.1,2 Plantar fascia, or plantar aponeurosis, supports the medial longitudinal...

Call For Papers


The Annals is the official journal of the Academy of Medicine, Singapore. Established in 1972, Annals is the leading medical journal in Singapore which aims to publish novel findings from clinical research as well as medical practices that can benefit the medical community.

Published monthly, online, open-access and peer-reviewed, Annals is indexed in Science Citation Index Expanded, Current Contents/Clinical Medicine and SCOPUS. The journal’s 2022 Impact Factor is 5.2. It is ranked in the first quartile in the competitive category of Medicine (General and Internal) and second among medical journals in Asia. As we are transitioning to an Online Only journal, there may be a delay in PubMed indexing for our content.

The rapidly ageing population and enlarging burden of chronic diseases require a proportionate emphasis on health promotion and disease prevention. A health system that is more data-driven and patient-centric, which leverages the innovative use of technology and digital solutions, will be areas warranting research attention and coverage. The Annals invites submission of manuscripts that advance the scientific basis of clinical knowledge, and the practice of medicine in Singapore and internationally. We welcome submissions that address challenges in the management of chronic diseases (e.g. cancer, cardiovascular diseases, ageing, diabetes mellitus and neurological diseases), and use of technology and digital medicine to improve patient care.

Papers of sufficient merits will be published. Authors will also be notified if their manuscripts are deemed not suitable for publication.

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