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Volume 52, Number 8 August 2023

High exposure to heavy metals such as cadmium, lead, arsenic and mercury can cause nephrotoxicity.

A study highlights the protective effects of micronutrients against chronic kidney disease (CKD). While high blood levels of heavy metals increased the risk of CKD, elevated plasma selenium and serum zinc may interact with low-toxicity heavy metals to reduce CKD risk.

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Featured

Original Article

Plasma selenium and zinc alter associations between nephrotoxic metals and chronic kidney disease:...

Cheng-Jui Lin and others
Chronic kidney disease (CKD) is a clinical condition comprising persistent changes in kidney function or structure, or both. It is characterised by irreversible and progressive evolution, increasing the risk of complications and mortality. As the 16th leading cause of...
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Editorial

Micronutrients and kidney health

Boon Wee Teo, Xiaoli Peng
Chronic kidney disease (CKD) is a structural and functional disorder of the kidney caused by many diseases, such as diabetes, hypertension and glomerular disease.1 There are many factors that contribute to the development and progression of CKD, and often,...
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Original Article

Poorer outcomes following COVID-19 infection for patients with depression: A cohort analysis in...

Su Kyoung Lee and others
In the early days of the pandemic, a major public health focus was to slow the spread of COVID-19. Therefore, the emphasis was on protecting the elderly, immunocompromised, and patients with respiratory and other underlying medical conditions. However, as...
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Editorial

Impact of pre-existing depression on severe COVID-19 outcomes

Meng Sha, Yong-bing Qian, Qiang Xia
The outbreak of the COVID-19 virus in 2019 had rapidly developed into a global pandemic, causing more than 6.8 million deaths and impacting the lives of billions of individuals around the world.1 Public healthcare around the work have mainly...
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Original Article

Fetal congenital heart diseases: Diagnosis by anatomical scans, echocardiography and genetic tests

Abhiram Kanneganti and others
Congenital heart diseases (CHDs) are the most common major congenital anomaly at up to 28%1 and are responsible for 5.7% of all infant mortality.2 While earlier studies in developed countries reported an overall CHD birth prevalence of 3.7–5.54 per...
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Original Article

Association of anticoagulation use during continuous kidney replacement therapy and 90-day outcomes: A...

Yie Hui Lau and others
Acute kidney injury (AKI) affects 21.6% of critically ill adult patients,1 with 5–7% requiring kidney replacement therapy (KRT).2 AKI carries significant prognostic and socioeconomic implications—chronic kidney disease (CKD) progression over 1 year has been described in 21%, 30%, and...
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Letter to the Editor

Breast conservation treatment and frozen section analysis of margins

Mona P Tan and Clement Luck Khng Chia and others
Dear Editor,  Re. Surgical margins assessment reduces re-excision rates in breast-conserving surgery I read with interest the article by Woon et al. published in a recent issue of the Annals on the reduction of re-excision rates with the use of intraoperative...
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Letter to the Editor

Managing and preventing severe hand injuries among sugarcane juicer operators

Zhi Xuan Low and others
Dear Editor, Of all hand injuries encountered at an emergency department, 54% are sustained in the workplace,1 in part contributed by occupational injuries among food and beverage operators that caused a loss of 16,197 man-hours in 2021 alone.2 Commonplace in...
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Letter to the Editor

Outcomes of nurse-led cryotherapy treatment for viral warts

Benjamin Liang Jun Lui, Chris Lixian Tan
Dear Editor,  Cryotherapy is a cost-effective treatment that can be performed by non-dermatologists for viral warts, which are very common.1,2 The National University Hospital, Singapore runs a nurse-led wart clinic where nurses are trained to administer cryotherapy. This study reviewed...
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Letter to the Editor

Evaluation on the adoption of eHealth App for electronic health record sharing system...

Junjie Huang and others
Dear Editor, In Hong Kong, the eHealth App was launched in January 2021, as part of Stage Two development of the Electronic Health Record Sharing System. It provides the healthcare recipients, that is, those who have registered in the system,...
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Original Article

Association between genetic polymorphisms in fibrinogen genes and bleeding risk in patients treated...

Kyung Hee Choi and others
Direct oral anticoagulants (DOACs) are widely prescribed for the prevention and treatment of stroke, systemic embolism and venous thromboembolism.1 Their mechanism of action involves direct binding to and inhibition of activated coagulation factors—factor Xa and thrombin—thereby preventing excessive blood...
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Editorial

Incorporating assessment of fibrinogen gene polymorphisms and bleeding risk in patients treated with...

William Ying Khee Hwang, Chuen Wen Tan, Heng Joo Ng
Direct oral anticoagulants (DOACs) have become entrenched as the dominant anticoagulant over the last decade for patients with venous thrombosis and atrial fibrillation.1 Compared to warfarin, bleeding risk is similar or lower for patients on DOACs but clinically relevant...
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Call For Papers

The Annals is the official journal of the Academy of Medicine, Singapore. Established in 1972, Annals is the leading medical journal in Singapore which aims to publish novel findings from clinical research as well as medical practices that can benefit the medical community.

Published monthly, online, open-access and peer-reviewed, Annals is indexed in Index Medicus, Science Citation Index – Expanded, ISI Alerting Services, and Current Contents/ Clinical Medicine. The journal’s 2022 Impact Factor is 5.2. It is ranked in the first quartile in the competitive category of Medicine (General and Internal) and second among medical journals in Asia..

The rapidly ageing population and enlarging burden of chronic diseases require a proportionate emphasis on health promotion and disease prevention. A health system that is more data-driven and patient-centric, which leverages the innovative use of technology and digital solutions, will be areas warranting research attention and coverage. The Annals invites submission of manuscripts that advance the scientific basis of clinical knowledge, and the practice of medicine in Singapore and internationally. We welcome submissions that address challenges in the management of chronic diseases (e.g. cancer, cardiovascular diseases, ageing, diabetes mellitus and neurological diseases), and use of technology and digital medicine to improve patient care.

Papers of sufficient merits will be published. Authors will also be notified if their manuscripts are deemed not suitable for publication.

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MOST CITED ARTICLES

Commentary

Mental Health Strategies to Combat the Psychological Impact of Coronavirus Disease...

Cyrus SH Ho, Cornelia YI Chee, Roger CM Ho
Review Article

Review on Epidemic of Obesity

Serena Low, Mien Chew Chin, Mabel Deurenberg-Yap
Review Article

Rationale for Redefining Obesity in Asians

Serena Low and others
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