Original Article
Burden of antibiotic resistance in infections among very-low-birthweight infants in Singapore
Recent reports have described an increased predominance of Gram-negative organisms (Escherichia coli, Klebsiella species ) among invasive bacterial infections in early- and late-onset neonatal...
Original Article
Real-world data on the use of emicizumab in patients with haemophilia A with and without inhibitors in Singapore
Haemophilia A is an X-linked hereditary bleeding disorder caused by pathogenic genetic variants, which results in a deficiency of factor VIII (FVIII).1 The mainstay...
Review Article
AL amyloidosis: Singapore Myeloma Study Group consensus guidelines on diagnosis, treatment and management
Amyloidosis refers to disorders characterised by the deposition of insoluble amyloid fibrils, which are pathogenic,1 resulting in organ dysfunction. Amyloidoses differ in the protein...
Original Article
Risk of dementia in the elderly with non-alcoholic fatty liver disease: A nested case-control study in the Republic of Korea
Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease affecting about 25% of the general population.1,2 NAFLD has a broad disease...
Editorial
Paradigm shifts in haemophilia A therapy with emicizumab prophylaxis in Asia
Over the past decade, the development of emicizumab, the first-in-class factor VIII (FVIII)-mimetic monoclonal antibody bispecific to activated factor IX and factor X, has...
Editorial
Improving management of AL amyloidosis
In this issue of the Annals, Tan et al. on behalf of Singapore Myeloma Study Group presented the consensus guidelines on light chain (AL)...
Original Article
Clinical utility of PET/MRI in multiple myeloma
Multiple myeloma (MM) is a haematological malignancy characterised by abnormal accumulation of malignant plasma cells and is associated with anaemia, renal impairment, hypercalcemia and...
Review Article
Improving visual outcomes in patients with rare paediatric eye diseases
Rare diseases are generally understood as those that affect less than 1 in 2000–2500 people in the general population.1 They are defined to affect...
Commentary
Value the patient as a person: Answering the call for a person-centred model of care
There has been a change in patients’ attitudes towards healthcare professionals in recent decades, coupled with an increasingly evident shift in the care paradigm....
Letter to the Editor
The practice patterns and perceptions of surgeons in Singapore regarding breast-conserving surgery
Dear Editor,
Breast-conserving surgery (BCS) is often the preferred treatment in operable breast cancer.1 While tumour biology and systemic therapy are major determinants of disease...
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