• Vol. 41 No. 2, 44–46
  • 15 February 2012

Current Strategies in Management of Duchenne Muscular Dystrophy: Allowing Patients to Live with Hope

153



153 Views
19 Downloads

Download PDF

Duchenne muscular dystrophy (DMD) is inherited as an X-linked recessive disorder which affects 1 in 3600 to 6000 live male births and is the most common childhood neuromuscular disorder. Most patients present with delayed motor milestones or proximal muscle weakness and are diagnosed at 5 years of age, when their physical ability diverges markedly from that of their peers. Non-progressive cognitive dysfunction, learning disability and autism are recognised features of the disease. Untreated, these boys have loss of independent ambulation by the age of 9 to 12 years. The mean age at death without intervention is around 19 years, with the leading causes of death being respiratory insufficiency, followed by cardiac complications such as dilated cardiomyopathy.

This article is available only as a PDF. Please click on “Download PDF” on top to view the full article.