• Vol. 37 No. 10, 831–834
  • 15 October 2008

Ertapenem for Treatment of Extended-spectrum Beta-lactamase-producing and Multidrug-resistant Gram-negative Bacteraemia

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ABSTRACT

Introduction: Imipenem and meropenem are treatment of choice for extended-spectrum beta-lactamase (ESBL)-positive gram-negative bacteraemia. They may select for carbapenem-resistant Acinetobacter baumannii and Pseudomonas aeruginosa; ertapenem may not do so as it is inactive against these bacteria. Clinical efficacy of ertapenem in ESBL-producing gram-negative bacteraemia is limited.

Materials and Methods: Retrospective study of patients with ESBL-positive gram-negative bacteraemia treated with ertapenem was undertaken.

Results: Forty-seven patients with multidrug-resistant gram-negative bacteraemia (79% produced ESBL) were treated with ertapenem for a median duration of 11 days. The median age was 70 years. Septic shock occurred in 19% and mechanical ventilation was needed in 17%. Klebsiella pneumoniae comprised 53% and Escherichia coli 26%. Urinary infection accounted for 61% and hepatobiliary 15%. Favourable clinical response occurred in 96%. Attributable mortality was 4%.

Conclusion: Ertapenem is promising in culture-guided step-down therapy of ESBL-positive gram-negative bacteraemia.


Extended-spectrum beta-lacatamase (ESBL)-producing gram-negative bacteraemia is optimally treated with carbapenem. In our institution, Escherichia coli and Klebsiella pneumoniae are the most common and third most common causes of bacteraemia, and 21% of E. coli and 51% K. pneumoniae produced ESBL.

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