We would like to present a case report on a 10-year-old Singaporean boy, John (name has been changed to preserve patient’s confidentiality), diagnosed with Down syndrome
(DS) (nondysjunction 47, XY+21) at birth and subsequently displaying autism-like behaviours. He was diagnosed with global development delay and attended special education programmes since 5 years of age. His parents and siblings displayed typical development. At 10 years 11 months, John underwent a comprehensive clinical assessment in view of concerns of autism-like behaviours. He was assessed on: (i) Autism Diagnostic Interview-Revised (ADI-R); (ii) Autism Diagnostic Observation Schedule (ADOS); (iii) Vineland Adaptive Behavior Scale (VABS); and (iv) Aberrant Behavior Checklist (ABC). In addition, results from blood tests revealed that he had normal thyroid function.
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