• Vol. 31 No. 3, 353–356
  • 15 May 2002

Four Pregnancies in Two Patients with Essential Thrombocythaemia—A Case Report

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ABSTRACT

Introduction: We report our experience of 4 pregnancies in 2 patients who had essential thrombocythaemia (ET).

Clinical Picture: Two patients with ET were managed with a variety of therapeutic approaches including the use of low-dose aspirin, plateletpheresis, hydroxyurea and alpha-interferon in the course of their 4 pregnancies.

Treatment and Outcome: One patient had 2 successful pregnancies despite having platelet counts in excess of 1000 x 109/L antenatally. The second patient had an intrauterine fetal death during the third trimester of her first pregnancy but had a successful second pregnancy.

Conclusion and Clinical Implications: Management of ET in pregnancy is still very much individualised. The impact of various treatment modalities on the pregnancy outcome remains to be proven but a favourable pregnancy outcome is possible.


Essential thrombocythaemia (ET) is a rare myeloproliferative disease which manifests with an elevated platelet count. It presents predominantly in the middle-aged population, occurring slightly more frequently in women than men.

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