ABSTRACT
Genetically manipulated animals generated by transgenic and gene-targeting (knockout) technology have contributed tremendously to our understanding of gene function and regulation at the molecular level in the context of the whole organism. They are also becoming powerful tools for human disease studies and therapeutic drug development. An overview of the current development of these animals and their application in biological and medical researches is provided in this article.
Animals have long served as experimental models for studying human biology and diseases. With the biomolecular revolution in the past three decades, genetically manipulated animals are playing increasingly important roles in our efforts to create and expand the various animal models for experimental research.
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