Haemoglobin E-beta thalassaemia (Hb E/β-thalassaemia) is a common cause of thalassaemia major in Southeast Asia. In Singapore, the prevalence of beta thalassaemia (β-thalassaemia) trait is 0.9% and haemoglobin E (HbE) trait is 0.55% . This is especially high in the Malay ethnic group. According to the National Thalassaemia Registry, the Malay population accounts for 74% of the registered subjects with Hb E/β-thalassaemia.
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