Henoch-Schönlein purpura (HSP) is an immunoglobulin (Ig) A–mediated small vessel vasculitis that occurs uncommonly among adults and even more rarely in individuals infected with the human immunodeficiency virus (HIV). There are overlapping clinical features between HIV-associated nephropathy, HSP and secondary IgA nephropathy. However the systemic associations of HSP are uncommon in the other 2 conditions. The management is also very different. We report a case of a Singaporean man with HIV infection, who presented with classical signs and symptoms as well as pathologic findings consistent with adult HSP.
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