Hepatocellular carcinoma (HCC) is one of the relatively aggressive neoplasms. Although extrahepatic metastasis of HCC to various organs is frequently discerned, metastasis to the spleen is extremely rare. To date, only scattered case reports have been illustrated.1-3 We report 1 case with hepatitis B surface antigen (HBsAg) negative and HCV-antibody negative who initially presented with huge splenic mass caused by HCC.
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