Histoplasmosis is a fungal infection which when disseminated can be potentially fatal, especially in the immunocompromised patient. Disseminated histoplasmosis can present with orolaryngeal manifestations which often mimic carcinoma or tuberculosis. A high index of suspicion and diagnosis with biopsy is needed. Two recent cases are presented and the literature reviewed. As the number of immunocompromised patients increases, more cases of histoplasmosis in the head and neck will be encountered. Early treatment can reduce morbidity and mortality.
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The author(s) declare there are no affiliations with or involvement in any organisation or entity with any financial interest in the subject matter or materials discussed in this manuscript.
