• Vol. 48 No. 4
  • 15 April 2019

HLA-B*5701 Genotyping for Abacavir Prescription: Re- Examination of its Cost-Effectiveness in Singapore



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Abacavir is a nucleoside reverse transcriptase inhibitor
(NRTI) that is used to control disease progression of human
immunodeficiency viruses (HIV). It reduces the morbidity
and mortality of HIV infections.1 A serious side effect of
abacavir is hypersensitivity reaction (HSR) which usually
begins within 6 weeks of starting treatment and manifests
as fever, malaise, nausea, vomiting and rashes. In severe
cases, it results in multiple organ system failure.

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