Clearly, schizophrenia does not readily lend itself to finding simple answers. As well as being clinically heterogeneous, it is not a disorder of one brain region or even one network of regions. Findings from brain imaging studies are varied, and while consistent patterns are apparent (e.g. structural abnormalities in frontal cortex, temporal lobe, and subcortical regions),1-3 these are not always observed at earlier illness stages and may not be apparent pre-psychosis onset.4,5
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