• Vol. 27 No. 5, 722–724
  • 15 September 1998

Invasive Cancer after Treatment of Cervical Intraepithelial Neoplasia



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This review discusses the risk of invasive cancer following treatment for cervical intraepithelial neoplasia (CIN). The emphasis is on methods in current use and the risks are calculated with life table methods.

Large, long-term follow up studies which use life table analysis show clearly that invasive recurrences continue to appear at a relatively steady rate for at least 8 years after treatment for CIN. The risk remains 4 to 5 times greater than in the background population throughout this period. It would seem prudent to continue to offer these women increased surveillance with annual smears during this time of increased risk.

All modern methods of outpatient treatment are highly effective in preventing invasive cancer of the cervix if they are used skilfully with an understanding of the disease being treated. The thoughtless use of beguilingly easy methods will lead only to disaster.

The objective of a cervical screening programme is to prevent invasive cancer of the cervix by detecting and treating pre-invasive disease of the cervix. The impact of the programme depends both on the detection of women with cervical intraepithelial neoplasia (CIN) and upon their being treated effectively.

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