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Volume 44, Number 8
August 2015

Angiotensin 2 Type 1 Receptor Blockade with Neprilysin Inhibition for Chronic Heart Failure: A New Paradigm?

A new treatment for heart failure (HF) combining angiotensin 2 type 1 receptor blockade with inhibition of the widespread membrane-bound enzyme, neprilysin (NEP), seems...

Electrocardiographic Criteria for Left Ventricular Hypertrophy in Asians Differs from Criteria Derived from Western Populations—Community-based Data from an Asian Population

Traditionally, the diagnosis and assessment of left ventricular hypertrophy (LVH) was made with the use of electrocardiography (ECG) and echocardiography, and more recently, with...

Thyroid Autoimmune Antibodies and Major Depressive Disorder in Women

Autoimmune thyroid diseases such as Graves’ disease and Hashimoto’s thyroiditis are defined by elevated serum levels of anti-thyroid antibodies and thyroid hormone dysfunction. Anti-thyroid...

Genomics of Hereditary Colorectal Cancer: Lessons Learnt from 25 Years of the Singapore Polyposis Registry

The significant advancements of genomic information for colorectal cancer (CRC) have been made largely in the last quarter of the century. The loss of...

Disseminated Bacillus Calmette-Guérin and Susceptibility to Mycobacterial Infections—Implications on Bacillus Calmette-Guérin Vaccinations

Tuberculosis (TB) is endemic in Asia. Out of 22 countries with high TB burden, 10 are Asian countries. Bacillus Calmette-Guérin (BCG) vaccine is one...