• Vol. 40 No. 11, 488–492
  • 15 October 2011

KCNQ1 Variants Associate with Type 2 Diabetes in Malaysian Malay Subjects



Introduction: Type 2 diabetes (T2D) candidate gene: potassium voltage-gated channel, KQT-like subfamily, member 1 (KCNQ1) was suggested by conducting a genome wide association study (GWAS) in Japanese population. Association studies have been replicated among East Asian populations; however, the association between this gene and T2D in Southeast Asian populations still needs to be studied. This study aimed to investigate the association of KCNQ1 common variants with type 2 diabetes in Malaysian Malay subjects.

Materials and Methods: The KCNQ1 single nucleotide polymorphisms (SNPs): rs2237892, rs2283228, and rs2237895 were genotyped in 234 T2D and 177 normal Malay subjects.

Results: The risk allele of the rs2283228 (A) was strongly associated with T2D (OR = 1.7, P = 0.0006) while the rs2237892 (C) was moderately associated with T2D (OR = 1.45, P = 0.017). The recessive genetic models showed that rs2283228 was strongly associated with T2D (OR = 2.35, P = 0.00005) whereas rs2237892 showed a moderate association with T2D (OR = 1.69, P = 0.01). The haplotype block (TCA), which contained the protective allele, correlated with a protection from T2D (OR = 0.5, P = 0.003). Furthermore, the diplotype (CAA-TCA) that contained the protective haplotype was protected against T2D (OR = 0.46, P = 0.006).

Conclusion: The KCNQ1 SNPs, haplotypes and diplotypes are associated with T2D in the Malaysian Malay subjects.

Diabetes is the most common metabolic disease that affects 246 million people worldwide. The International Diabetes Federation (IDF) predicts that the total number of people living with diabetes will increase to 380 million within the next 20 years. Diabetes, mostly type 2 diabetes mellitus (T2D), now affects 5.9% of the world’s adult population, with almost 80% of patients originating from developing countries. More than 1.3 million Malaysians have diabetes and the IDF has predicted that this number would be doubled by 2025.

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