• Vol. 42 No. 3, 120–124
  • 15 March 2013

Kidney Cancer and Diabetes Mellitus: A Population-Based Case-Control Study in Taiwan



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Introduction: The purpose of this study was to explore whether diabetes mellitus (DM) correlates with the risk of kidney cancer in Taiwan.

Materials and Methods: We designed a population-based case-control study from the Taiwan National Health Insurance Database, which consisted of 116 patients with newly diagnosed kidney cancer as cases and 464 subjects without kidney cancer as controls in 2000 to 2009. Both cases and controls were aged ≥20 years. Baseline comorbidities were compared between kidney cancer cases and controls.

Results: Multivariable analysis showed no association was detected between DM and kidney cancer (OR 1.06, 95% CI, 0.58 to 1.94). Hypertension (OR 2.05, 95% CI, 1.23 to 3.42), chronic kidney diseases (OR 2.57, 95% CI, 1.23 to 5.37), cystic kidney diseases (OR 18.6, 95% CI, 1.84 to 187.6) and kidney stones (OR 4.02, 95% CI, 2.43 to 6.66) were signifi cant comorbidities associated with increased risk of kidney cancer. Use of alpha-glucosidase inhibitor was associated with increased risk of kidney cancer (OR 4.31, 95% CI, 1.07 to 17.3).

Conclusion: DM does not correlate with the risk of kidney cancer. Hypertension, chronic kidney diseases, cystic kidney diseases, kidney stones and use of alpha-glucosidase inhibitors are associated with kidney cancer.

Kidney cancer accounts for 3% to 4% of all cancers. In a systematic review by Mathew and et al,2 the incidence of kidney cancer was the highest in France (16.1 per 100,000
man-years) and the lowest in India (0.9 per 100,000 woman-years) during 1988 to 1992. A trend analysis in North America by Sun et al3 showed that the age-adjusted incidence of renal cell carcinoma rose from 7.6 per 100,000 person-years in 1988 to 11.7 per 100,000 person-years in 2006. This incidence has been increasing substantially in the world, but varies markedly. In Taiwan, kidney cancer was ranked the eighteenth leading cause of cancer death in 2010 and the current mortality rate was around 2.0 to 2.3 per 100,000 persons in 2006 to 2010.

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