Mitochondrial myopathy, encephalopathy, lactic acidosis and stroke (MELAS) syndrome is a progressive neurodegenerative disorder with variable clinical presentations. Neuropsychiatric manifestations include mood disturbances, obsessive compulsive features and neurocognitive deficits. We report a case of pathological hyperemotionalism associated with MELAS syndrome which has not been documented previously in the literature, according to the best of our knowledge.
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