An 83-year-old Chinese lady was diagnosed with right locally advanced breast cancer in August 2008. Histology of core biopsies showed infiltrative ductal carcinoma grade III. Estrogen and progesterone receptors were positive, Cerb-B2 negative. CT scan showed right breast tumour extending to the skin surface with ipsilateral axillary and supraclavicular lymphadenopathy. In view of her frail health contributed by multiple medical comorbidities, surgical therapy and chemotherapy were deemed to be too risky. She was started on tamoxifen for 3 months but switched to letrozole, with minimal response observed. She then underwent radiotherapy to her right breast in February 2009 for local control of her right breast mass.
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