• Vol. 33 No. 4 (Suppl), 63S–68S
  • 31 July 2004

Oral Pemphigus Vulgaris: A Case Report and Literature Update



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Introduction: Pemphigus vulgaris is a rare cause of oral mucosal ulceration.

Clinical Picture: A 47-year-old Chinese man presented with a 3-month history of oral ulceration. There were no lesions on the skin or other mucosal sites. Histology and immunostaining were consistent with pemphigus vulgaris.

Treatment: Systemic and topical corticosteroids were instituted, together with topical antifungals. Conventional periodontal therapy was carried out to improve gingival/oral health.

Outcome: Control of oral ulceration was achieved with re-establishment of normal oral function. No other sites to date have been involved.

Conclusions: Chronic oral ulceration can be the sole manifestation of pemphigus vulgaris, at least initially. Early recognition of this lesion may prevent delayed diagnosis and inappropriate treatment of a potentially chronic dermatological condition.

Autoimmune blistering conditions are an uncommon cause of chronic ulceration of the oral mucosa. Nevertheless, it is important to diagnose these conditions early and institute treatment as soon as possible, as they can lead to serious involvement in other mucosal and cutaneous sites and even death.

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