In subcutaneous panniculitis-like T-cell lymphoma
(SPTL), infiltration of subcutaneous tissue by pleomorphic
T-cells and benign macrophages is seen in skin nodules that
mimic lobular panniculitis. SPTL affects young patients
and about 20% develop haemophagocytic syndrome (HPS)
which worsens survival significantly.1,2 We describe a case
of aggressive SPTL in a patient with HPS who relapsed
after multiple lines of therapy, but achieved complete and
durable remission after extended pralatrexate therapy.
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