• Vol. 48 No. 9, 298–300
  • 15 September 2019

Pralatrexate Induces Long-Term Remission in Relapsed Subcutaneous Panniculitis-Like T-Cell Lymphoma


In subcutaneous panniculitis-like T-cell lymphoma (SPTL), infiltration of subcutaneous tissue by pleomorphic T-cells and benign macrophages is seen in skin nodules that mimic lobular panniculitis. SPTL affects young patients and about 20% develop haemophagocytic syndrome (HPS) which worsens survival significantly.1,2 We describe a case of aggressive SPTL in a patient with HPS who relapsed after multiple lines of therapy, but achieved complete and durable remission after extended pralatrexate therapy.

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