• Vol. 35 No. 10, 723–725
  • 15 October 2006

Recombinant Tissue Plasminogen Activator (r-TPA) in Fibrin Dissolution due to Postoperative Endophthalmitis



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Introduction: The aim of this paper was to describe the use of r-TPA for fibrin clot dissolution following endophthalmitis.

Clinical Picture: A 74-year-old man presented with painful loss of vision following routine uncomplicated cataract surgery.

Treatment: He underwent standard treatment for postoperative endophthalmitis but despite this, developed a dense fibrin clot. He underwent further intracameral injection of r-TPA.

Outcome: Following the injection, he had complete clot dissolution within 2 hours without any complications.

Conclusion: R-TPA may be used effectively in the treatment of fibrin clots secondary to endophthalmitis following cataract surgery.

Cataract surgery is one of the most successful surgical procedures performed. However, postoperative endophthalmitis, defined as severe inflammation involving both the anterior and posterior segments of the eye secondary to an infectious agent, is an uncommon but devastating complication.

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