ABSTRACT
Introduction: The SCAN colorectal cancer systemic therapy workgroup aimed to develop Singapore Cancer Network (SCAN) clinical practice guidelines for systemic therapy for colorectal cancer in Singapore
Materials and Methods: The workgroup utilised a modified ADAPTE process to calibrate high quality international evidence-based clinical practice guidelines to our local setting. Results: Five international guidelines were evaluated—those developed by the National Comprehensive Cancer Network for colon (2014) and rectal (2014) cancer, the European Society of Medical Oncology for advanced (2012) and early (2013) cancer and the National Institute of Clinical Excellence (2011). Recommendations on systemic therapy in colorectal cancer were produced. Conclusion: These adapted guidelines form the SCAN Guidelines 2015 for systemic therapy of colorectal cancer.Globally, colorectal cancer (CRC) is the third most common cancer with 1 million new cases per year. In Singapore, CRC is the most common cancer (8206 new cases, 2006 to 2010), accounting for 18% and 14% of all cancers in males and females respectively. One in 25 male and 1 in 35 female Singaporeans will develop CRC in their lifetime. Adjuvant postoperative systemic therapy is recommended for patients with stage III CRC and considered for patients with high risk stage II CRC. About half of CRC patients develop metastatic disease (either at diagnosis or as systemic recurrence after initial early stage CRC). Systemic therapy improves quality of life and overall survival (OS) in patients with stage IV CRC.
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