• Vol. 44 No. 10, 484–491
  • 15 October 2015

Singapore Cancer Network (SCAN) Guidelines for the Initial Evaluation, Diagnosis and Management of Retroperitoneal Soft Tissue Sarcoma



Introduction: The SCAN sarcoma workgroup aimed to develop Singapore Cancer Network (SCAN) clinical practice guidelines for the initial evaluation, diagnosis and management of patients with retroperitoneal soft tissue sarcoma.

Materials and Methods: The workgroup utilised a modified ADAPTE process to calibrate high quality international evidence-based clinical practice guidelines to our local setting.

Results: Various international guidelines from the fields of radiology, pathology, surgical, medical and radiation oncology were reviewed. Recommendations on the role of radiological imaging, pathology, surgery, radiotherapy and systemic therapy in the management of retroperitoneal soft tissue sarcoma were developed.

Conclusion: These guidelines form the SCAN Guidelines 2015 for the diagnosis, staging and optimal management of patients with retroperitoneal soft tissue sarcoma.

Soft tissue sarcoma (STS) is a rare and heterogeneous group of cancers representing <1% of all newly diagnosed malignancies. As an entity, it is made up of more than 50 pathologically and molecularly distinct subtypes of sarcomas. Originating at any site in the body, approximately 15% of STS originate from the retroperitoneal region. Based on the National Cancer Centre Singapore’s (NCCS) sarcoma database, the 3 most common STS histotypes include well differentiated/dedifferentiated liposarcoma, leiomyosarcoma and undifferentiated pleomorphic sarcoma (UPS) (formerly termed malignant fibrous histiocytoma).

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