• Vol. 44 No. 10, 449–462
  • 15 October 2015

Singapore Cancer Network (SCAN) Guidelines for the Use of Systemic Therapy in Advanced Non-Small Cell Lung Cancer



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Introduction: The SCAN lung cancer workgroup aimed to develop Singapore Cancer Network (SCAN) clinical practice guidelines for the use of systemic therapy in advanced non-small cell lung cancer (NSCLC) in Singapore.

Materials and Methods: The workgroup utilised a modified ADAPTE process to calibrate high quality international evidence-based clinical practice guidelines to our local setting.

Results: Five international guidelines were evaluated—those developed by the National Comprehensive Cancer Network (2014), the European Society of Medical Oncology (2014), the National Institute of Clinical Excellence (2012), the Scottish Intercollegiate Guidelines Network (2014) and Cancer Care Council Australia (2012). Recommendations on systemic treatment for advanced NSCLC were produced.

Conclusion: These adapted guidelines form the SCAN guidelines 2015 for systemic therapy of advanced or metastatic NSCLC.

Non-small cell lung cancer (NSCLC) ranks as one of the most frequent cancers in Singapore with a total of 6407 new cases diagnosed from 2008 to 2012. It remains the most lethal of all cancers, being the top cause of cancer death in men and second most lethal cancer in women. Majority of patients (74.5%) are in advanced stages (III/ IV) at point of diagnosis.

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