• Vol. 41 No. 5, 200–204
  • 15 May 2012

SOX40L: An Important Inflammatory Mediator in Adult Bronchial Asthma

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ABSTRACT

Introduction: The role of soluble OX40 ligand (sOX40L) in adult bronchial asthma is unclear. This study aims to determine the serum concentrations of sOX40L in adult patients with bronchial asthma, and discussed its relationship with pulmonary function.

Materials and Methods: We measured the pulmonary function using the spirometer and detected the serum concentrations of sOX40L by enzyme linked immunosorbent assay (ELISA) in 19 healthy persons in the control group, 58 acute asthmatic adult patients who were grouped according to their disease severity: 18 mild grade, 24 moderate grade, 16 severe grade, and 24 persons in a stable asthmatic group.

Results: The serum concentrations of sOX40L in asthmatic adult patients (6.80 ± 4.95 ng/L) were distinctly higher than those in the control group (3.98 ± 2.83 ng/L, P <0.05), and they were negatively correlated with pulmonary function indexes (FEV1%, FVC%, FEV1/FVC) (r = –0.754, P <0.01, r = –0.557, P <0.01, r = –0.457, P <0.01, respectively). Moreover, the serum concentrations of sOX40L showed obvious differences among control, mild, moderate, and severe groups (3.98 ± 2.83, 4.87 ± 1.89, 6.97 ± 5.91, 8.71 ± 5.18 ng/L, respectively; P <0.01). The concentrations of sOX40L decreased to the same extent as the control group after therapeutic treatments were provided to the asthmatic adult patients.

Conclusion: The concentrations of sOX40L were found to be high in adult asthmatic patients and were associated with the severity of the disease. Therefore, sOX40L could be a potential inflammatory mediator in the pathogenesis of asthma.


Bronchial asthma is a kind of chronic airway inflammatory disease which is associated with the infiltration of eosinophils, mastocytes, and T lymphocytes, and the release of several inflammatory mediators. These inflammatory mediators play an important role in the pathogenesis of asthma. Recent studies suggest that many co-stimulatory molecules such as CD30, tumour necrosis factor receptor (TNFR), CD40, CD40L, B7-H3etc exist in membrane forms and soluble forms. In many diseases, these soluble molecules are highly important in disease diagnosis, severity assessment, clinical staging, and disease prognosis.

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