• Vol. 32 No. 2, 219–225
  • 15 March 2003

The Molecular Biology of Peritoneal Carcinomatosis from Gastrointestinal Cancer

140



140 Views
21 Downloads

Download PDF

ABSTRACT

Introduction: Peritoneal carcinomatosis is a frequent form of disease progression in gastrointestinal cancer, and all too often is a preterminal event with a median survival of only 6 months. Despite the introduction of aggressive surgical and chemotherapeutic approaches, any significant improvement in survival is unlikely until we better understand the molecular biology of peritoneal metastasis.

Methods: A Medline search and review of references was undertaken to identify all manuscripts in the English language concerned with peritoneal metastasis from gastrointestinal cancer.

Results: Peritoneal carcinomatosis involves a complex sequence of interdependent steps. The injured peritoneum is a rich source of cytokines and growth factors that facilitate tumour proliferation and invasion in the postoperative abdomen. Peritoneal tumour adhesion is dependent on adhesion molecules, such as CD44, and the ß-1 integrins. Invasion of the mesothelium involves, at least in part, a process of tumour-induced mesothelial apoptosis. Matrix metalloproteinases, such MMP-7, facilitate stromal invasion, but the role of other proteases in invasion remains to be elucidated. To date, the significance of angiogenesis in the peritoneal metastatic cascade is unknown.

Conclusion: The molecular biology of peritoneal carcinomatosis is only just beginning to be understood. Further research into the mediators of the peritoneal metastatic cascade is needed if more effective therapeutic strategies are to be developed for this invariably fatal, yet unfortunately common, condition.


The term “peritoneal carcinomatosis” was first used by Sampson in 1931 to describe the intra-abdominal spread of ovarian carcinoma. Although ovarian cancers account for the majority of cases, peritoneal carcinomatosis is also frequently associated with gastrointestinal malignancies.

This article is available only as a PDF. Please click on “Download PDF” on top to view the full article.