• Vol. 37 No. 3, 188–191
  • 15 March 2008

The Relation Between Insulin Resistance Determined by Haemostatic Modelling and Slow Coronary Flow



Introduction: In this study, we sought to determine whether insulin resistance, which is investigated by homeostatic modelling, is related to slow coronary flow (SCF).

Materials and Methods: A total of 24 patients with SCF (4 females/20 males, mean age 47 ± 12 years) and 32 patients with normal coronary artery (10 females/22 males, mean age 52 ± 12 years) were included in the study. Baseline glucose, insulin and plasma lipid levels were measured. A standard oral glucose tolerance test (OGTT) was performed and post-challenge insulin levels were also measured. The index of insulin resistance was calculated with the homeostatic modelling [homeostatic model assessment for insulin resistance index (HOMA-IR)].

Results: There were no differences between the 2 groups with regard to age, lipid levels, blood pressure levels, history of smoking, fasting and post-challenge plasma glucose. Baseline insulin levels were augmented in the SCF group (9.64 ± 5.93 vs 7.04 ± 3.26, P = 0.041). HOMA-IR levels were not different between the study groups (2.20 ± 1.44 vs 1.69 ± 0.86, P = 0.129). Manifest insulin resistance was significantly higher in the CSF group as compared with the control group (25% vs 3%, P = 0.01).

Conclusion: Manifest insulin resistance is seen more frequently in patients with SCF.

Slow coronary flow (SCF) is a well recognised clinical entity, characterised by delayed opacification of coronary arteries in the presence of normal coronary angiogram. Many aetiological factors, such as microvascular and endothelial dysfunction, have been implicated.

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