The authors sought to give a perspective of the local use of two atypical neuroleptics which may represent a new era in the treatment of schizophrenia. The findings from local drug trials and clinical reports are summarised. Both clozapine and risperidone are efficacious in reducing the psychotic symptomatology of schizophrenia as well as inducing less extrapyramidal side-effects. Differences in plasma clozapine levels were found in local Chinese patients when compared to American subjects. Combined use of clozapine and risperidone may give rise to adverse reactions. Both clozapine and risperidone are efficacious and safe in the treatment of schizophrenia.
Schizophrenia is the most severe of all mental disorders and affects about 1% of the population. The main disturbances of schizophrenia comprise positive symptoms, negative symptoms and disorganisation.
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