• Vol. 48 No. 8, 274–278
  • 15 August 2019

White Matter Disease in a Young Adult Presenting as Rapidly Progressive Parkinsonism


A 36-year-old Chinese lady presented with bilateral hand tremors and difficulty in performing simple tasks such as typing and handling of utensils. She also reported short-term memory loss over the last 3 months. On initial examination, bradykinesia was observed in her upper limbs which was slightly more pronounced on the left. This was associated with postural and intention tremors as well as left upper limb dystonia, posturing and apraxia. Brisk tendon reflexes were also elicited. Her sensory and motor power and coordination examinations were unremarkable. Her gait and speech were normal.

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