Systemic lupus erythematosus (SLE) is a multisystemic autoimmune disease characterised epidemiologically by the preponderance of women, and pathologically by the loss of immunological tolerance to self-nuclear antigens and aberrant B- and T-cell responses. Similar to that of other regions around Southeast Asia, the prevalence of SLE in Singapore is...

Erythroderma is a dermatological reaction characterised by extensive erythema and scaling of the skin secondary to a variety of causes. An improved understanding of the characteristics and aetiologies of this condition will guide management. In this retrospective study, we aim to describe the characteristics and explore the associated causes...

The prevalence of diabetes mellitus in Singapore is increasing. It was at its highest of 11.3% in the latest National Health Survey 2010 compared to 8.2% in 2004. Diabetic foot wounds are serious complications of diabetes mellitus and can lead to limb loss if left untreated. Diabetics have a...

Rheumatoid arthritis (RA) is a chronic autoimmune disease affecting 0.3% to 0.8% of the population worldwide, and is the most common inflammatory arthritis in Singapore. Suboptimally treated RA may result in irreversible joint damage, serious extra-articular manifestations, and comorbidities including osteoporosis6 and cardiovascular disease, with substantial adverse impact on...

The World Health Organization (WHO) estimates that every year, almost a million people die from suicide — a mortality rate of 16 per 100,000, or 1 death every 40 seconds. WHO also posits that in some countries, suicide is one of the three leading causes of death among those...