Alzheimer’s disease (AD) is a progressive fatal neurodegenerative disease whose numbers are approaching epidemic proportions as the world’s population ages. There are currently 35 million victims worldwide with an anticipated 115 million by 2050 if effective treatments are not found. There is an urgent need to identify treatments that...

Since the birth of the Academy of Medicine (AM) in 1957, many members have contributed to the postgraduate specialist training and championed the maintenance of high standards of competency and ethical integrity among medical and dental specialists in Singapore. While its relative focus has evolved over the years, AM...

Cone beam computed tomography (CBCT) is a relatively new technological innovation which utilises flat-panel detector technology to obtain CT-like axial images. The radiation source beam and flat panel detector are coupled together by a C-arm. In a single 180-degree rotation of the C-arm (Fig. 1), a typical CBCT unit...

Down’s syndrome (DS) is the most common chromosome abnormality in mankind. Previously, patients underwent invasive prenatal diagnostic tests, such as chorionic villus sampling and amniocentesis, to detect chromosomal abnormalities. However, these invasive procedures have an intrinsic risk of foetal loss. In Mainland China, second trimester double-marker analysis remains the...

Non-small-cell lung cancer (NSCLC) is the leading cause of cancer-related deaths worldwide, with a 5-year survival of around 15%. Approximately 20% of patients present with stage I disease (T1N0M0 or T2N0M0) and undergo potentially curative surgical resection. However, approximately 30% to 40% of patients with stage I NSCLC after...