Most Cited Articles

Integrating traditional Chinese medicine into disease management in Singapore

Traditional Chinese medicine (TCM) was introduced to the Singapore population by early Chinese immigrants from China.1 During Singapore’s colonial era, particularly between 1819 to...

Evaluating the impact of relative dose intensity on efficacy of trastuzumab deruxtecan for metastatic breast cancer in the real-world clinical setting

Human epidermal growth receptor 2 (HER2)-positive breast cancer is recognised as a particularly aggressive subtype, associated with a poorer prognosis and a higher risk...

Utilising a COM-B framework to modify antibiotic prescription behaviours following third molar surgeries

Antimicrobial resistance (AMR) is a critical global public health crisis, associated with 4.7 million deaths worldwide in 2021 alone.1 Antibiotic stewardship is one of...

Health-related quality of life in Singapore: Population norms for the EQ-5D-5L and EORTC QLQ-C30

Health-related quality of life (HRQOL) is a multidimensional assessment of the impact of disease and treatment on physical, psychological and social aspects of individuals’...

Premature ovarian insufficiency: When ovaries retire early

Illustration by LadyFingers Co. Premature ovarian insufficiency (POI, also known as primary ovarian insufficiency) refers to loss of ovarian activity before the age of 40...

Adolescent self-harm and suicide attempts: An analysis of emergency department presentations in Singapore

Within 3 years from 2019 to 2021, adolescent suicide rates in Singapore almost doubled from 5.35 to 9.14 per 100,000 population.1,2 This is against...

Prevalence of complexity in primary care and its associated factors: A Singapore experience

As Singapore’s population ages, the incidence of non-communicable chronic diseases will rise in tandem.1 There exists a subset of individuals, oftentimes elderly with multiple...

Epidemiology of paediatric intensive care unit admissions, deaths and organ donation candidacy: A single-centre audit

With advancements in medical care, mortality rates in critically ill patients have decreased substantially.1,2 Contemporary studies from developed countries report paediatric intensive care mortality...

Pharmacogenomics in psychiatry: Practice recommendations from an Asian perspective (2024)

Pharmacogenomic testing in psychiatry is an emerging area with the potential clinical application of guiding medication choice and dosing. Interest in this area has...

Factors influencing smoking cessation: Insights from Singapore’s nationwide health and lifestyle survey

The global prevalence of smoking has declined over the years. According to authors utilising data from the Global Burden of Disease, Injuries, and Risk...