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A Case Report of the Use of Magnesium Sulphate during Anaesthesia in a Patient...
Phaeochromocytomas are catecholamine-secreting tumours of the chromaffin cells of the body derived from neural crest tissue. They may secrete both adrenaline and noradrenaline in...
Sandhoff Disease—A Case Report of 3 Siblings and a Review of Potential Therapies
Sandhoff disease is a rare inborn error of metabolism characterised by the absence of both β-hexosaminidase A and B, resulting in an accumulation of...
A Case Report on the Perinatal Management of a 30-week Preterm Baby with Congenital...
The association between congenital complete heart block (CHB) and maternal autoimmune disorders has been described for many years. Maternal systemic lupus erythematosus (SLE) is...
The Role of Cytokines and Cytokine Gene Polymorphism in T-cell Activation and Allograft Rejection
Cytokines are peptide molecules that are responsible for intercellular signalling during immune activation events. Cytokines are responsible, in large part, for the regulation of...
Hereditary Breast Cancer: A Brief Overview
Worldwide, breast cancer is the third most common form of cancer, after lung and stomach cancer, and it is the most common form among...
Pharmacogenetics: The Molecular Genetics of CYP2D6 Dependent Drug Metabolism
CYP2D6 is a cytochrome P450 isoenzyme that plays a role in the metabolism of a wide range of drugs, particularly cardiovascular and psychotropic agents....
Genetics of Male Infertility: Role of Androgen Receptor Mutations and Y-Microdeletions
Three to four per cent of men have severe defects in sperm production that result in infertility. Most of these men are healthy and...
The Molecular Pathogenesis of Obesity: An Unfinished Jigsaw Puzzle
Obesity is one of the most common health problems in Singapore with escalating prevalence, affecting about 6% of the Singapore population above 18 years...
Proteinuria and Angiotensin Converting Enzyme (ACE) Gene Polymorphism
Proteinuria is considered a marker of renal disease. Traditionally it has been thought that proteinuria is the result of diseased glomeruli.
This article is available...
The Role of Single Nucleotide Polymorphisms (SNPs) in Understanding Complex Disorders and Pharmacogenomics
With the Human Genome Project well underway and targeted to be completed by 2001, the full set of nucleotide sequences of a reference human...