Despite accelerated research and major advances in the treatment of asthma in recent years, the disease burden remains high even in well resourced countries where up to 50% of patients may experience poor control of clinical disease. This is a global challenge which calls for a robust collective response....

Despite advances in resuscitation, survival from paediatric in-hospital cardiac arrests (IHCA) remains poor. Reported peri-resuscitative factors associated with mortality include pre-existing haematological, oncological, immunologic, genetic or metabolic disorders; presence of endotracheal tube or use of vasoactive infusions before arrest; use of adrenaline, calcium or sodium bicarbonate during arrest; and duration...

Anaphylaxis is a severe and potentially fatal allergic reaction that occurs rapidly after exposure to an allergen. There have been reports that the incidence of paediatric anaphylaxis is on the rise in the industrialised world. There is, however, limited data confirming these trends in the Asian population. This article is available...

Both the quantity and quality of sleep affect the normal development of preschool children. Insufficient sleep quantity and poor sleep quality—defined as short sleep duration, long sleep latency, and low sleep efficiency— are common among schoolchildren and also preschool children. Studies from Asia have shown that delayed bedtimes, reduced...

Extended-spectrum beta-lactamases (ESBLs) are rapidly expanding groups of enzymes that can hydrolyse the majority of beta-lactam antibiotics with the exception of carbapenems, and are inhibited by clavulanic acid. They are commonly found on plasmids, which are extra-chromosomal deoxyribonucleic acid (DNA) that can transfer between bacteria. ESBL-producing Enterobacteriaeceae (ESBL-E) frequently cause...