Review Article
Medical Treatment of Osteoporosis—Increasing Options
The current practice and management of osteoporosis differs greatly from even the recent past. Up to 15 years ago, bone mineral density (BMD) measurements...
Orthopaedic Implant Infections: Current Management Strategies
Orthopaedic joint replacement and spinal stabilisation surgery have provided pain relief and functional improvement for millions. Postoperative infections involving implanted hardware can have devastating...
Prognostic Factors in Endometrial Carcinoma
In the United States of America, endometrial carcinoma is the most common cancer of the female genital tract and has an annual incidence of...
Recent Developments of Informed Consent in Eye Research
Two recent court rulings1 have underlined the global trend of relying on the principles of medical ethics of autonomy or self-determination of the individual...
Age-related Macular Degeneration – An Asian Perspective
Age-related macular degeneration (AMD) is a group of non-Mendellian disorders which share the common manifestation of chronic progressive degeneration of the macula involving changes...
Oral Tolerance: Mechanisms and Therapy of Autoimmune Diseases
Immunologic tolerance is a hallmark of the immune system whereby immune cells are tolerant of self antigen. Historically, this tolerance was thought to be...
Chemoprevention of Colorectal Cancer – Experimental Approach and Clinical Applications
The age-old adage of “Prevention is Better than Cure” is still very relevant in today’s practice of medicine. Many randomised population trials have already...
Three New Cases of Leishmaniasis: Implications for the Singapore Medical Community
Although visceral and cutaneous leishmaniasis are important clinical and public health problems worldwide, these diseases are not endemic in Singapore and the medical profession...
Risk Adjustment: Towards Achieving Meaningful Comparison of Health Outcomes in the Real World
Consider these hypothetical situations. Patients with heart failure managed within a disease management programme are found to have reduced hospitalisations and improved quality of...
Clinical Aspects and Management of Fibromyalgia Syndrome
Fibromyalgia syndrome (FMS) has been referred to as a medically unexplained syndrome;1,2 a rheumatological entity described in rheumatology textbooks and taught to all training...