Review Article
Murine Metastatic Tumour Models for Cancer Gene Therapy Research
In the evaluation of any new cancer treatment, the use of appropriate experimental animal tumour models to bridge the gap between in vitro discovery...
Experimental Models of Hepatic Fibrosis in the Rat
Hepatic fibrosis and cirrhosis of the liver are complex diseases which, in man, may be caused by such varied factors as alcohol, hepatitis, schistosomiasis,...
Development of the Human Intrahepatic Biliary System
The development of the human biliary system has been studied extensively. This knowledge is essential to the understanding of the pathogenesis of a spectrum...
Regulation of Insulin Secretion by Nerves and Neuropeptides
The pancreatic islets of Langerhans were described by Paul Langerhans in 1869. They are distributed throughout the entire pancreas forming in adults approximately 1%...
Diabetic Retinopathy
Diabetes mellitus affects some 9% of Singaporeans. Studies had shown that virtually all insulin dependent diabetes mellitus (Type 1) and 85% of non-insulin dependent...
Analytical Static Stress Analysis of First Cervical Vertebra (Atlas)
Fractures of the atlas comprise approximately 25% of all injuries to the atlanto-axial complex, 10% of all injuries of the cervical spine, and about...
Theory and Practice in Continuing Medical Education
A physician’s education in medical science represents a continuum of several interrelated phases. It starts with medical school, passes through brief housemanship year, and...
Sleep/Wake Cycle and Circadian Disturbances in Shift Work: Strategies for Their Management—A Review
Humans have primarily been active/awake during the day and inactive/asleep at night. The discovery of artificial light and introduction of electric power generator have...
The efficacy and safety of high-intensity focused ultrasound in the treatment of benign thyroid...
Thyroid nodules are commonly seen in clinical practice. They can be detected by palpation in 5%1 of individuals and by ultrasound (US) in 19–68%...
Cardiac Effects of Psychotropic Drugs
The incidence of mortality is higher among psychiatric patients than among the general population and the cause of which may be the psychiatric disorder...