Volume 52, Number 2
February 2024

A study group from Taiwan investigated drug-drug interactions in patients with nonvalvular atrial fibrillation, a type of irregular heartbeat.

They concluded that the concurrent use of particular inducers increases the risk of bleeding events.

Illustration by Nata Blackthorn

Direct oral anticoagulant: Looking beyond convenience

Since the 2010 Food and Drug Administration approval of Dabigatran as the first non-vitamin-K antagonist oral anticoagulants or direct oral anticoagulants (DOACs) as it is now more commonly referred to, there has been much development in the field with increasing availability of different DOACs and an expansion in indications...

Breast cancer-related lymphedema (BCRL): Should we be doing more or less for the axilla?

Breast cancer mortality has declined steadily over the years with breast cancer screening, and improvement in diagnostic and therapeutic regimens. Despite cancer survivors living longer, breast cancer-related lymphedema (BCRL) is a significant complication after major breast surgery that can impact quality of life adversely. The incidence of BCRL reported...

Effect of drug interactions with non-vitamin-K oral anticoagulants on thromboembolic events in patients with nonvalvular atrial fibrillation

Atrial fibrillation (AF), a type of arrhythmia for which the incidence and prevalence are rising in the older population, has become a global epidemic.1 The estimated prevalence of AF is approximately 2% to 4%,2,3 and its prevalence is projected to increase by 2.3-fold by 2030.3 Older patients with AF...

Defining breast cancer-related lymphedema (BCRL) prevalence and risk factors: A pragmatic approach to lymphedema surveillance

Breast cancer-related lymphedema (BCRL) is a chronic progressive pathological condition of the lymphatic system that can lead to significant impact on the quality of life after breast cancer treatment.1 It is characterised by swelling and accumulation of protein-rich fluid in body tissues, leading to pain, tightness, skin changes such...

Frailty-aware surgical care: Validation of Hospital Frailty Risk Score (HFRS) in older surgical patients

Frailty is a clinically recognisable state of vulnerability in older people, resulting from age-associated decline in physiological reserves and function across multiple organ systems, such that the ability to cope with acute stressors is compromised.1 Frailty is prevalent among older people2 and is associated with higher rates of utilisation...

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Board of Reviewers 2024

Organ donation in the paediatric intensive care unit: Time for change?