Volume 54, Number 2
February 2025

Research explores the latest advanced role, mechanism, treatment and safety of hydroxychloroquine (HCQ) in rheumatic diseases during pregnancy and application prospects of HCQ in preeclampsia.

Illustration by Maria De-Castro

Mechanisms and roles of hydroxychloroquine in pregnancy in rheumatic diseases

With the prevalence of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) around the world, hydroxychloroquine (HCQ) has once again come into public attention due to its potential therapeutic role in COVID-19. HCQ is a classic antimalarial drug that belongs to the 4-aminoquinoline phospholipase A2 inhibitors. It was first introduced...

Prevalence of complexity in primary care and its associated factors: A Singapore experience

As Singapore’s population ages, the incidence of non-communicable chronic diseases will rise in tandem.1 There exists a subset of individuals, oftentimes elderly with multiple chronic conditions, whose care needs are particularly complex.2 While there is no universal definition of a person with complex needs, these individuals have been found...

Navigating health challenges: Singapore’s National University Health System’s approach to child and family well-being

Dear Editor, Singapore’s progressive commitment to addressing child and family well-being is anchored in its forward-thinking public health agenda. Recognising that long-term population health outcomes are shaped by early-life interventions, Singapore has directed increasing attention towards addressing complex health challenges that emerge during childhood and across the family unit. These...

Navigating the risks of contrast extravasation in CT scans: A 3-year study of 26,544 automated power injector cases

Dear Editor, We present findings from our large-scale retrospective study on contrast media extravasation (CME) in computed tomography (CT) examinations. Over 3 years, we analysed 26,544 adult CT examinations with intravenous contrast media administered via a power injector to determine CME incidence and evaluate associated risk factors. CME is a recognised...

Infected ovarian endometrioma: Case series and management outcomes

Illustration by LadyFingers Co. Dear Editor, Infected endometrioma, which is the superimposed infection and abscess formation of ovarian endometrioma, is increasingly understood to be a distinct clinical entity from tubo-ovarian abscess (TOA). The pathophysiology of infected endometriosis has been postulated to be a result of endometriotic fluid acting as a culture...

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