Volume 52, Number 3
Genetic testing in patients with metastatic castration-resistant prostate cancer primarily aims to identify targetable mutations. However, the results of genetic testing may uncover unanticipated hereditary mutations and genetic predisposition.
The latest review proposes a model to incorporate genetic testing in routine clinical practice. A brief pre-test counselling by managing clinicians followed by somatic testing can reduce current bottlenecks at genetic counselling stage, for early commencement of therapy. Early detection strategies for patients harbouring genetic mutations are critical to increase overall survival and quality of life.
Illustration by Xinyu Li
Editorial
Challenges with mainstreaming genetic testing for metastatic prostate cancer treatment in Singapore
Compared with other solid tumours, patients with metastatic prostate cancer typically have better survival in the range of years.1 The long survival translates to a high prevalence, and thus, a large number of men living with prostate cancer. Singapore has one of the highest age-standardised incidence rates of prostate...
Editorial
Preventing recurrent hypersensitivity reactions to iodinated contrast media
Iodinated contrast media (ICM) is one of the most commonly used drugs in the practice of modern medicine. ICM, as the name implies, is a contrast media that contains iodine. It is frequently used in computed tomography (CT) and angiographic procedures, to highlight important anatomical structures and for the...
Original Article
Clinical outcomes and management of contrast hypersensitivity in patients requiring repeated computed tomography imaging
Allergic and non-allergic hypersensitivity reactions to iodinated contrast media (ICM) are increasingly recognised, particularly the latter where there is greater clarity on pathomechanisms.1 There is limited evidence for the use of corticosteroids as premedication to prevent the occurrence of contrast-related reactions. At our institution, a dose of 30mg oral...
Original Article
Association between lower phase angle and chronic kidney disease progression in type 2 diabetes patients
Chronic kidney disease (CKD) is a global public health problem with an estimated prevalence of 13.4%.1 One of the key drivers of the global increase in CKD is the rising prevalence of diabetes mellitus (DM).1 CKD affects about 25–40% of patients with type 2 diabetes mellitus (T2DM).2 A few...
Review Article
An approach to genetic testing in patients with metastatic castration-resistant prostate cancer in Singapore
Prostate cancer is the fifth most common cancer in Asian men, and with its rising incidence, is emerging as a health priority in Asia.1 Across Asian countries, age-standardised incidence rates (ASIRs) of prostate cancer range from 0.9 to 56.1 per 100,000 population, with the second highest ASIR reported in...
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Original Article
