Volume 53, Number 5
Performance of classification criteria for systemic lupus erythematosus (SLE) in Asian childhood-onset SLE (cSLE) population remains unclear as clinical manifestations differ.
This study evaluates the criteria used to diagnose SLE, a disease often referred to as lupus (Latin for "wolf"). It examines an East Asian cohort with childhood onset, predominantly female, with a median diagnosis age of 12.9 years.
Illustration by Ladyfingers Co.
Original Article
Prevalence and risk factors of depression and anxiety in primary care
The global prevalence of individuals living with a mental disorder in 2019 was 970 million, with anxiety and depressive disorders being the most common.1 The Singapore Mental Health Study 2016 showed that the lifetime prevalence of at least one mood, anxiety or alcohol use disorder was 13.9% in the...
Letter to the Editor
Comparing the effectiveness, safety and cost of teleconsultation versus face-to-face model of pharmacist-led anticoagulation clinic: A single institution experience
Dear Editor,
Teleconsultation-based (TELE) anticoagulation clinic (ACC) is an alternative modality, but its use in Singapore’s clinical setting has not been well studied. In Tan Tock Seng Hospital (TTSH), the TELE ACC service was established to enrol patients who (1) perform self-testing using a loaned point-of-care (POC) international normalised ratio...
Original Article
Diagnostic performance of classification criteria for systemic lupus erythematosus: A validation study from Singapore
Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease with a broad spectrum of clinical presentation.1 Clinical diagnosis by rheumatologists remains the gold standard, but the diagnosis is often challenging due to variability in disease expression mimicking other conditions.
As such, classification criteria have been developed to establish homogeneous groups...
Original Article
Delayed presentation is associated with serious bacterial infections among febrile infants: A prospective cohort study
Young infants ≤90 days old are at risk of serious bacterial infections (SBIs) due to their immature immune systems and may develop severe complications resulting in neurocognitive deficits, hearing loss and even mortality.1,2 The diagnosis of SBIs remains challenging as fever may be the only symptom of SBIs in...
Review Article
Holistic preconception care: Providing real-time guidance via a mobile app to optimise maternal and child health
Global fertility rates have decreased by more than half since 1950, recorded at 2.3 births per woman in 2021.1 By 2056, this figure is projected to decline further to 2.09, which falls below the replacement fertility rate of 2.1 children per woman.1 In Singapore, the fertility rate has reached...
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Board of Reviewers