Volume 51, Number 11
Multisystem inflammatory syndrome in children (MIS-C) is a rare inflammatory syndrome with multisystem involvement affecting children exposed to COVID-19. It emerged in Singapore as the incidence of COVID-19 in the community increased in 2021.
A Singapore observational study on cases fulfilling the Ministry of Health criteria for MIS-C from January 2020 to December 2021 was conducted in the country’s biggest paediatrics hospital. All patients had mucocutaneous features similar to Kawasaki disease, frequently presenting with haematological, gastrointestinal and cardiovascular symptoms.
Multidisciplinary management, timely diagnosis, and early treatment with intravenous immunoglobulin and steroids likely contributed to good outcomes.
Illustration by Xinyu Li
Editorial
Multisystem inflammatory syndrome in children: A unique manifestation of COVID-19
During the coronavirus disease 2019 (COVID-19) pandemic, children have been relatively spared from the severe symptomatic infection affecting adults, particularly the elderly and those with comorbidities. One of the most challenging aspects of paediatric SARS-CoV-2 infection has been the discovery of a unique late manifestation of infection characterised by...
Original Article
Multisystem inflammatory syndrome in children in Singapore
While children infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) resulting in coronavirus disease 2019 (COVID-19) have milder manifestations compared to adults,1,2 a rare multisystem inflammatory syndrome leading to multiorgan failure and shock (multisystem inflammatory syndrome in children ) has been recognised to affect children with exposure to...
Original Article
Improving drug allergy label accuracy by supervised safety- and protocol-driven evaluation
Self-reported drug allergies1 are common, and the majority of these have been shown to be inaccurate. Recording of drug allergy details is also often incomplete and inaccurate.2 Consequences of inaccurate drug labelling include unnecessary avoidance of effective medications, restricted access to appropriate antibiotics, impact on antimicrobial stewardship, and public...
Original Article
Non-alcoholic fatty liver disease screening in type 2 diabetes mellitus: A cost-effectiveness and price threshold analysis
Non-alcoholic fatty liver disease (NAFLD) is a growing epidemic and has become a major cause of liver-related mortality and indication for liver transplantations globally. It is estimated that nearly 25% of the world’s population and more than 60% of type 2 diabetes mellitus (T2DM) patients have NAFLD. A prior...
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National surgical antibiotic prophylaxis guideline in Singapore
Surgical antibiotic prophylaxis (SAP) refers to the administration of antibiotics prior to clean and clean-contaminated surgeries to prevent postoperative surgical site infections (SSIs). An optimal SAP should be highly effective in preventing SSI. An ideal prophylactic antibiotic regimen is: (1) effective against pathogens—generally skin flora—most likely to contaminate the...
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