Multisystem inflammatory syndrome in children (MIS-C) is a rare inflammatory syndrome with multisystem involvement affecting children exposed to COVID-19. It emerged in Singapore as the incidence of COVID-19 in the community increased in 2021.

A Singapore observational study on cases fulfilling the Ministry of Health criteria for MIS-C from January 2020 to December 2021 was conducted in the country’s biggest paediatrics hospital. All patients had mucocutaneous features similar to Kawasaki disease, frequently presenting with haematological, gastrointestinal and cardiovascular symptoms.

Multidisciplinary management, timely diagnosis, and early treatment with intravenous immunoglobulin and steroids likely contributed to good outcomes.

^{Illustration by Xinyu Li}