Review Article
The Role of Surgery in High-grade Glioma – Is Surgical Resection Justified? A Review...
High-grade glioma (malignant glioma) is the most common primary intra-axial tumour of the central nervous system (CNS). Despite recent therapeutic advances in glioma treatment,...
Insights into the Cancer Stem Cell Model of Glioma Tumorigenesis
Solid tumours are histologically heterogeneous and include tumour cells, stroma, inflammatory infiltrates and vascular structures. There is now much evidence that in cancers, a...
Review of Human Infections with Avian Influenza H5N1 and Proposed Local Clinical Management Guideline
The current human H5N1 outbreak occurred in Hong Kong for the first time in 1997, with another 2 human cases in the same city...
Evaluating the Optic Nerve and Retinal Nerve Fibre Layer: The Roles of Heidelberg Retina...
Glaucoma is an optic neuropathy with characteristic optic nerve damage and visual field loss. With the introduction of the ophthalmoscope by Helmholtz in 1851,...
Seronegative Spondyloarthropathy – Studies from the Asia Pacific Region
Seronegative spondyloarthropathies (SpA), a group of arthritides characterised by axial skeletal involvement and the absence of rheumatoid factor, are now enjoying a resurgence of...
The Use of Biological Agents in the Treatment of Rheumatoid Arthritis
The treatment of rheumatoid arthritis (RA) has gone through many major changes in the past 100 years. Historically, it was essentially untreatable and many...
Computational Immunology – From Bench to Virtual Reality
The pace at which data is being generated in both the basic and clinical sciences has been growing exponentially in recent years, driven by...
Health-related Quality of Life in Patients with Systemic Lupus Erythematosus: An Update
Systemic lupus erythematosus (SLE) is a multi-system autoimmune disease associated with significant morbidity and mortality. With improvements in survival in SLE, attention has also...
Emerging Therapies in Stroke Rehabilitation
Stroke is the fourth leading cause of death in Singapore since 1998.1 While mortality due to stroke has steadily declined over the years with...
Recovery and Regeneration after Spinal Cord Injury: A Review and Summary of Recent Literature
Spinal cord injury (SCI), whether of traumatic or non-traumatic aetiology, often results in significant and catastrophic dysfunction and disability. It physically and psychologically affects...