Review Article
Colorectal Cancer Liver Metastases – Understanding the Differences in the Management of Synchronous and...
Colorectal cancer (CRC) is one of the commonest cancers worldwide with age standardised incidence rates of 22.8 to 64.2 and 19.0 to 46.7 per...
Pathophysiology and Animal Models of Schizophrenia
Schizophrenia is a debilitating condition with a mean lifetime morbidity risk of approximately 1:100.1 The current diagnosis of schizophrenia is based primarily on DSM...
Cognitive Dysfunction in Schizophrenia: A Perspective from the Clinic to Genetic Brain Mechanisms
In Singapore, the prevalence of mental health problems is suggested to be about 16.6%.1 Schizophrenia, the focus in this review, affects about 1% of...
Measuring Memory-Prediction Errors and their Consequences in Youth at Risk for Schizophrenia
Despite the common experience of the world as mostly stable and meaningful, the human nervous system continuously engages with a vast array of ambiguous...
Potential Endophenotype for Schizophrenia: Neurological Soft Signs
The past decades have witnessed many research endeavours to understand neurological soft signs (NSS) in schizophrenia and its related disorders. These efforts mainly focused...
Psychosocial Factors in the Neurobiology of Schizophrenia: A Selective Review
The architecture of the neurobiology of schizophrenia is complex: it comprises an inherited vulnerability with multiple genes involved, and its interaction with a number...
Neurobiology of Schizophrenia Spectrum Disorders: The Role of Oxidative Stress
The brain is, weight for weight, the most metabolically active tissue in the body and generates a high load of reactive oxygen moieties. This...
The Transplantable Organ Shortage in Singapore – Has Implementation of Presumed Consent to Organ...
The first transplant operation was a successful kidney transplantation between identical twins performed on 23 December 1954 at the Peter Bent Brigham Hospital in...
Allogeneic Haematopoietic Stem Cell Transplantation without a Matched Sibling Donor: Current Options and Future...
Allogeneic haematopoietic stem cell transplantation (HSCT) has been used to treat a variety of malignant and non-malignant diseases, particularly of the blood and immune...
Paradigm Shifts in Corneal Transplantation
The major advances in corneal transplantation over the last 50 years, have been due to the development of the microsurgical microscope, improvements in microsurgical...