Volume 51, Number 4
April 2022

Sepsis is a life-threatening complication that occurs when the body responds to an infection attacking the host. A narrative review in this issue highlights that circular RNAs (circRNAs) might exert pivotal roles in regulating the immune system against pathogens and sepsis-induced organ damage.

Investigating the regulation of circRNAs in sepsis could uncover new molecular targets for diagnosis and intervention. Such an understanding will be important for the development of therapeutic drugs.

Polycystic ovary syndrome in Singapore

Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in young women, affecting approximately 10% of women. It is a heterogeneous condition that...

Circular RNAs and sepsis: New frontiers in diagnostics and therapeutics?

Circular RNAs (circRNAs) are a group of endogenous RNAs characterised by their covalently closed-loop structures. These molecules are part of a large class of...

Diagnosis and management of polycystic ovary syndrome: Perspectives of clinicians in Singapore

Polycystic ovary syndrome (PCOS) is a common endocrine disorder estimated to affect 4–21% of women, depending on the diagnostic criteria used.1 Clinical manifestations of the...

Comparison of planned-start, early-start and deferred-start strategies for peritoneal dialysis initiation in end-stage kidney disease

Peritoneal dialysis (PD) is a well-established long-term dialysis modality for patients with end-stage kidney disease (ESKD).1 It is recommended that a PD catheter should...

Circular RNAs in the pathogenesis of sepsis and their clinical implications: A narrative review

Sepsis is a condition with life-threatening organ dysfunction, resulting from abnormal responses of the host to various infections.1 The underlying pathogenic mechanisms include an...


Review on Epidemic of Obesity

Rationale for Redefining Obesity in Asians