Sepsis is a life-threatening complication that occurs when the body responds to an infection attacking the host. A narrative review in this issue highlights that circular RNAs (circRNAs) might exert pivotal roles in regulating the immune system against pathogens and sepsis-induced organ damage.

Investigating the regulation of circRNAs in sepsis could uncover new molecular targets for diagnosis and intervention. Such an understanding will be important for the development of therapeutic drugs.