Volume 51, Number 4
Sepsis is a life-threatening complication that occurs when the body responds to an infection attacking the host. A narrative review in this issue highlights that circular RNAs (circRNAs) might exert pivotal roles in regulating the immune system against pathogens and sepsis-induced organ damage.
Investigating the regulation of circRNAs in sepsis could uncover new molecular targets for diagnosis and intervention. Such an understanding will be important for the development of therapeutic drugs.
Editorial
Polycystic ovary syndrome in Singapore
Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in young women, affecting approximately 10% of women. It is a heterogeneous condition that can present with a wide spectrum of signs and symptoms, including acne, hirsutism, obesity, menstrual irregularities and infertility. It is a complex trait that is...
Editorial
Circular RNAs and sepsis: New frontiers in diagnostics and therapeutics?
Circular RNAs (circRNAs) are a group of endogenous RNAs characterised by their covalently closed-loop structures. These molecules are part of a large class of non-coding RNAs that includes microRNAs (miRNAs) and long non-coding RNAs (lncRNAs). CircRNAs were initially thought to be of low abundance and represent errors in splicing....
Original Article
Diagnosis and management of polycystic ovary syndrome: Perspectives of clinicians in Singapore
Polycystic ovary syndrome (PCOS) is a common endocrine disorder estimated to affect 4–21% of women, depending on the diagnostic criteria used.1 Clinical manifestations of the syndrome are varied, and multiple parameters are needed for its diagnosis.2,3 This complicates the diagnosis of PCOS and may cause patient dissatisfaction arising from delayed...
Original Article
Comparison of planned-start, early-start and deferred-start strategies for peritoneal dialysis initiation in end-stage kidney disease
Peritoneal dialysis (PD) is a well-established long-term dialysis modality for patients with end-stage kidney disease (ESKD).1 It is recommended that a PD catheter should be placed at least 2 weeks prior to the anticipated need of long-term PD treatment for a planned-start PD.2 Despite wide-spread promotion of planned-start dialysis for...
Review Article
Circular RNAs in the pathogenesis of sepsis and their clinical implications: A narrative review
Sepsis is a condition with life-threatening organ dysfunction, resulting from abnormal responses of the host to various infections.1 The underlying pathogenic mechanisms include an imbalanced inflammatory response, immune disorder, neuroendocrine abnormality, coagulopathy, mitochondrial damage and endoplasmic reticulum stress.2 A recent study reported that the age-standardised sepsis incidence rate fell...
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Letter to the Editor
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Review Article
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