Tobacco use continues to impact health on a global scale. In 2015, 11.5% of all deaths worldwide (or a total of 6.4 million deaths) were attributable to tobacco, and more than half (52.2%) occurred in 4 countries—China, India, the United States (US) and Russia. This article is available only as...

The obesity epidemic is a major public health concern worldwide. In Singapore, 8.6% of the population has a body mass index (BMI) ≥30 kg/m2 and 34.3% of the population is overweight, i.e. BMI ≥25 kg/m2. This article is available only as a PDF. Please click on “Download PDF” on top to view...

Yellow fever (YF) is an arthropod-borne viral haemorrhagic disease transmitted by Aedes aegypti and Hemagogus mosquitoes, belonging to the flavivirus family which includes dengue, Zika and West Nile virus. Infected persons may have symptoms that range from subclinical infection to multi-organ failure and death. This article is available only as...

Laparoscopic surgery is widely used for the surgical treatment of rectal cancer. However, very low rectal cancer presents with special difficulty. Laparoscopic dissection beyond a protruding sacral promontory, especially in a small confined pelvic space in a fat male pelvis, is technically difficult. This article is available only as a...

Alexander disease (AD) is a progressive degenerative leukodystrophy, which typically presents in infancy. Neonatal, juvenile and adult-onset forms of AD are relatively rare, with a more variable clinical course compared to the infantile subtype. This article is available only as a PDF. Please click on “Download PDF” on top to view the full article.